The upper-airway microbiome as a biomarker of asthma exacerbations despite inhaled corticosteroid treatment.

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Abstract

The response to inhaled corticosteroids (ICS) in asthma is affected by the interplay of several factors. Among these, the role of the upper-airway microbiome has been scarcely investigated. We aimed to evaluate the association between the salivary, pharyngeal, and nasal microbiome with asthma exacerbations despite receipt of ICS.

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Journal

Journal ID (iso-abbrev): J Allergy Clin Immunol

Title: The Journal of allergy and clinical immunology

Publisher: Elsevier BV

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Mar 2023

Volume: 151

Issue: 3

Affiliations

[1 ] Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.

[2 ] Department of Biochemistry, Microbiology, Cell Biology and Genetics, ULL, La Laguna, Tenerife, Spain; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), ULL, La Laguna, Tenerife, Spain.

[3 ] Pulmonary Medicine Service, Hospital Universitario de NS de Candelaria, La Laguna, Tenerife, Spain; Pulmonary Medicine Section, Hospital Universitario de La Palma, La Palma, Spain.

[4 ] Severe Asthma Unit, Allergy Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.

[5 ] Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain; Department of Pediatrics, University of the Basque Country (UPV/EHU), San Sebastián, Spain.

[6 ] Allergy Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.

[7 ] Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.

[8 ] Allergy Service, Hospital Universitario NS de Candelaria, La Laguna, Tenerife, Spain.

[9 ] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain; Li Ka Shing Knowledge Institute at the St Michael's Hospital, Toronto, Ontario, Canada.

[10 ] Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, La Laguna, Tenerife, Spain. Electronic address: mdelpino@ull.edu.es.

[11 ] Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), ULL, La Laguna, Tenerife, Spain. Electronic address: florenzo@ull.edu.es.

Article

Publisher Item ID: S0091-6749(22)01475-0

DOI: 10.1016/j.jaci.2022.09.041

PubMed ID: 36343772

SO-VID: 90c15150-c14f-4438-aed7-96ffd47b3428

History

Keywords: saliva,exacerbations,biomarker,asthma,16S rRNA,inhaled corticosteroids,microbiota,nasal,pharyngeal,precision medicine

Data availability:

Keywords: saliva, exacerbations, biomarker, asthma, 16S rRNA, inhaled corticosteroids, microbiota, nasal, pharyngeal, precision medicine

The upper-airway microbiome as a biomarker of asthma exacerbations despite inhaled corticosteroid treatment.

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