For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
33
views
21
references
 Top references
cited by
6
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      55
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This study describes a scanning time-resolved fluorescence spectroscopy (TRFS) system designed to continuously acquire fluorescence emission and to reconstruct fluorescence lifetime images (FLIM) from a luminal surface by using a catheter-based optical probe with rotary joint and pull-back device. The ability of the system to temporally and spectrally resolve the fluorescence emission from tissue was validated using standard dyes and tissue phantoms (e.g., ex vivo pig aorta phantom). Current results demonstrate that this system is capable to reliably resolve the fluorescence emission of multiple fluorophores located in the lumen; and suggest its potential for intravascular detection of distinct biochemical features of atherosclerotic plaques.

          Related collections

          Most cited references21

          • Record: found
          • Abstract: not found
          • Article: not found

          Fluorescence lifetime measurements and biological imaging.

          Mikhail Y Berezin, Samuel Achilefu (2010)
          Article 0 comments Cited 479 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Solvent effects on emission yield and lifetime for coumarin laser dyes. Requirements for a rotatory decay mechanism

            Guilford Jones, William Jackson, Chol Yoo Choi … (1985)
            Article 0 comments Cited 122 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy.

              Noel Boens, Wenwu Qin, Nikola Basarić … (2007)
              A series of fluorophores with single-exponential fluorescence decays in liquid solution at 20 degrees C were measured independently by nine laboratories using single-photon timing and multifrequency phase and modulation fluorometry instruments with lasers as excitation source. The dyes that can serve as fluorescence lifetime standards for time-domain and frequency-domain measurements are all commercially available, are photostable under the conditions of the measurements, and are soluble in solvents of spectroscopic quality (methanol, cyclohexane, water). These lifetime standards are anthracene, 9-cyanoanthracene, 9,10-diphenylanthracene, N-methylcarbazole, coumarin 153, erythrosin B, N-acetyl-l-tryptophanamide, 1,4-bis(5-phenyloxazol-2-yl)benzene, 2,5-diphenyloxazole, rhodamine B, rubrene, N-(3-sulfopropyl)acridinium, and 1,4-diphenylbenzene. At 20 degrees C, the fluorescence lifetimes vary from 89 ps to 31.2 ns, depending on fluorescent dye and solvent, which is a useful range for modern pico- and nanosecond time-domain or mega- to gigahertz frequency-domain instrumentation. The decay times are independent of the excitation and emission wavelengths. Dependent on the structure of the dye and the solvent, the excitation wavelengths used range from 284 to 575 nm, the emission from 330 to 630 nm. These lifetime standards may be used to either calibrate or test the resolution of time- and frequency-domain instrumentation or as reference compounds to eliminate the color effect in photomultiplier tubes. Statistical analyses by means of two-sample charts indicate that there is no laboratory bias in the lifetime determinations. Moreover, statistical tests show that there is an excellent correlation between the lifetimes estimated by the time-domain and frequency-domain fluorometries. Comprehensive tables compiling the results for 20 (fluorescence lifetime standard/solvent) combinations are given.
              Article 0 comments Cited 72 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Biomed Opt Express
                Journal ID (iso-abbrev): Biomed Opt Express
                Journal ID (publisher-id): BOE
                Title: Biomedical Optics Express
                Publisher: Optical Society of America
                ISSN (Electronic): 2156-7085
                Publication date (Electronic): 06 June 2012
                Publication date Collection: 01 July 2012
                Publication date PMC-release: 06 June 2012
                Volume: 3
                Issue: 7
                Pages: 1521-1533
                Affiliations
                [1 ]University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA
                Author notes
                Article
                Publisher ID: 166495
                DOI: 10.1364/BOE.3.001521
                PMC ID: 3395478
                PubMed ID: 22808425
                SO-VID: 9068edb7-0db0-4f3f-9102-03298e8eed0b
                Copyright © ©2012 Optical Society of America
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.

                History
                Date received : 13 April 2012
                Date revision received : 25 May 2012
                Date accepted : 25 May 2012
                Funding
                Funded by: NIH
                Award ID: R01HL067377
                Categories
                Subject: Spectroscopic Diagnostics
                Custom metadata
                OpenAccess True
                OpenAccessEmbargo 0

                ScienceOpen disciplines: Vision sciences
                Keywords: (170.6935) tissue characterization,(300.6500) spectroscopy, time-resolved,(110.7170) ultrasound,(170.6510) spectroscopy, tissue diagnostics
                Data availability:
                ScienceOpen disciplines: Vision sciences
                Keywords: (170.6935) tissue characterization, (300.6500) spectroscopy, time-resolved, (110.7170) ultrasound, (170.6510) spectroscopy, tissue diagnostics

                Comments

                Comment on this article

                scite_

                Similar content55

                See all similar

                Cited by6

                See all cited by

                Most referenced authors345

                See all reference authors