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Intermediate filaments in disease
January 1995
January 1995
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Abstract
Intermediate filaments are major structural proteins encoded by a large multigene
family. Their tissue-specific expression makes them important in studies of development,
differentiation and pathology. Most intermediate filaments are keratins; recent discoveries
of keratin mutations in a range of genetic skin disorders have clarified their role
as providing essential structural support for cells in different physical settings.