Enhancement of Pulmozyme activity in purulent sputum by combination with poly-aspartic acid or gelsolin.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

DNase (Pulmozyme) effectiveness in cystic fibrosis treatment is in some cases limited by its inability to access DNA trapped within bundles in highly viscous fluids that also contain actin. Dissociating DNA-containing bundles using actin depolymerizing agents and polyanions has potential to increase DNase efficacy.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): J. Cyst. Fibros.

Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Publisher: Elsevier BV

ISSN (Electronic): 1873-5010

ISSN (Print): 1569-1993

Publication date (Electronic): Sep 2015

Volume: 14

Issue: 5

Affiliations

[1 ] Department of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: buckirobert@gmail.com.

[2 ] Department of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.

[3 ] Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA.

Article

Publisher Item ID: S1569-1993(15)00038-7

DOI: 10.1016/j.jcf.2015.02.001

PubMed ID: 25682700

SO-VID: 902f1732-8ce0-4742-8ec1-1a4866dde110

History

Keywords: Cystic fibrosis,Extracellular DNA,F-actin,Gelsolin,Poly-aspartic acid

Data availability:

Keywords: Cystic fibrosis, Extracellular DNA, F-actin, Gelsolin, Poly-aspartic acid

Enhancement of Pulmozyme activity in purulent sputum by combination with poly-aspartic acid or gelsolin.

Read this article at

Abstract

Related collections

Fandom activity

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 100

Cited by 9