The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease.

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Abstract

The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism may predict the risk of Alzheimer disease (AD). However, genetic association studies of the BDNF gene with AD have produced equivocal results. Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder.

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Journal

Journal ID (iso-abbrev): Arch Gen Psychiatry

Title: Archives of general psychiatry

Publisher: American Medical Association (AMA)

ISSN (Electronic): 1538-3636

ISSN (Print): 0003-990X

Publication date (Electronic): Feb 2011

Volume: 68

Issue: 2

Affiliations

[1 ] Department of Psychiatry, Geriatric Mental Health Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8. aristotle_voineskos@camh.net

Article

Publisher Item ID: 68/2/198

DOI: 10.1001/archgenpsychiatry.2010.194

PubMed ID: 21300947

SO-VID: 8f4a953d-1dd7-4050-9c9f-6eaf2d265918

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