Current Perspective in the Discovery of Anti-aging Agents from Natural Products

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans ( C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing anti-aging medicine from natural products.

Related collections

Most cited references 299

Record: found
Abstract: found
Article: found

Aging, Cellular Senescence, and Cancer

Judith Campisi (2013)

For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of which is cancer. In contrast to the loss of function that characterizes degenerating cells and tissues, malignant (cancerous) cells must acquire new (albeit aberrant) functions that allow them to develop into a lethal tumor. This review discusses the idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are at least partly linked by a common biological phenomenon: a cellular stress response known as cellular senescence. The senescence response is widely recognized as a potent tumor suppressive mechanism. However, recent evidence strengthens the idea that it also drives both degenerative and hyperplastic pathologies, most likely by promoting chronic inflammation. Thus, the senescence response may be the result of antagonistically pleiotropic gene action.

0 comments Cited 1132 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Jason Wood, Blanka Rogina, Siva Lavu … (2004)

Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.

0 comments Cited 459 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Biological and chemical approaches to diseases of proteostasis deficiency.

Evan T. Powers, Richard Morimoto, Andrew Dillin … (2009)

Many diseases appear to be caused by the misregulation of protein maintenance. Such diseases of protein homeostasis, or "proteostasis," include loss-of-function diseases (cystic fibrosis) and gain-of-toxic-function diseases (Alzheimer's, Parkinson's, and Huntington's disease). Proteostasis is maintained by the proteostasis network, which comprises pathways that control protein synthesis, folding, trafficking, aggregation, disaggregation, and degradation. The decreased ability of the proteostasis network to cope with inherited misfolding-prone proteins, aging, and/or metabolic/environmental stress appears to trigger or exacerbate proteostasis diseases. Herein, we review recent evidence supporting the principle that proteostasis is influenced both by an adjustable proteostasis network capacity and protein folding energetics, which together determine the balance between folding efficiency, misfolding, protein degradation, and aggregation. We review how small molecules can enhance proteostasis by binding to and stabilizing specific proteins (pharmacologic chaperones) or by increasing the proteostasis network capacity (proteostasis regulators). We propose that such therapeutic strategies, including combination therapies, represent a new approach for treating a range of diverse human maladies.

0 comments Cited 372 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Huai-Rong Luo: +86 871-65223225 , luohuairong@mail.kib.ac.cn

Journal

Journal ID (nlm-ta): Nat Prod Bioprospect

Journal ID (iso-abbrev): Nat Prod Bioprospect

Title: Natural Products and Bioprospecting

Publisher: Springer Singapore (Singapore )

ISSN (Print): 2192-2195

ISSN (Electronic): 2192-2209

Publication date (Electronic): 31 May 2017

Publication date PMC-release: 31 May 2017

Publication date Collection: October 2017

Volume: 7

Issue: 5

Pages: 335-404

Affiliations

[1 ]ISNI 0000000119573309, GRID grid.9227.e, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, , Chinese Academy of Sciences, ; Kunming, 650201 Yunnan China

[2 ]ISNI 0000 0004 1797 8419, GRID grid.410726.6, University of Chinese Academy of Sciences, ; Beijing, 100039 China

[3 ]Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000 Sichuan China

[4 ]ISNI 0000000119573309, GRID grid.9227.e, Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, , Chinese Academy of Sciences, ; Guangzhou, 510301 Guangdong China

[5 ]ISNI 0000000119573309, GRID grid.9227.e, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, , Chinese Academy of Sciences, ; 134 Lanhei Road, Kunming, 650201 Yunnan China

Article

Publisher ID: 135

DOI: 10.1007/s13659-017-0135-9

PMC ID: 5655361

PubMed ID: 28567542

SO-VID: 8ee57e30-d8b8-4c6b-bbe8-2cc51b46011e

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

History

Date received : 16 April 2017

Date accepted : 16 May 2017

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 81671405

Award ID: 81370453

Award Recipient : Huai-Rong Luo

Funded by: FundRef http://dx.doi.org/10.13039/501100005273, Natural Science Foundation of Yunnan Province;

Award ID: 2013FA045

Award ID: 2015FB172

Award Recipient : Huai-Rong Luo

Funded by: Open Funds of Guangdong Key Laboratory of Marine Materia Medica

Custom metadata

Keywords: aging,natural products,anti-aging,drug screening

Data availability:

Keywords: aging, natural products, anti-aging, drug screening

Comments

Comment on this article

scite_

Cited by 44

See all cited by

- Version 1

Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Read this article at

Abstract

Related collections

Algerian Journal of Natural Products

Most cited references 299

Aging, Cellular Senescence, and Cancer

Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Biological and chemical approaches to diseases of proteostasis deficiency.

Author and article information

Contributors

Journal

Affiliations

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 40

Cited by 44