Periostin is a novel therapeutic target that predicts and regulates glioma malignancy.

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Abstract

Periostin is a secreted matricellular protein critical for epithelial-mesenchymal transition and carcinoma metastasis. In glioblastoma, it is highly upregulated compared with normal brain, and existing reports indicate potential prognostic and functional importance in glioma. However, the clinical implications of periostin expression and function related to its therapeutic potential have not been fully explored.

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Author and article information

Journal

Journal ID (iso-abbrev): Neuro-oncology

Title: Neuro-oncology

ISSN (Electronic): 1523-5866

ISSN (Print): 1522-8517

Publication date (Electronic): Mar 2015

Volume: 17

Issue: 3

Affiliations

[1 ] Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington (A.M.M., S.A.M, S.N.E., C.A.P., R.G.O., J.R.S., R.C.R.); Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington (A.D.T.); Division of Medical Genetics, Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington (M.J.T); Department of Bioengineering, University of Washington School of Medicine, Seattle, Washington (S.F., D.-H.K.); Department of Radiology, University of Washington School of Medicine, Seattle, Washington (K.R.T.-F.); Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington (A.M.M., S.A.M., S.F., D.-H.K., R.C.R.); Sage Bionetworks, Seattle, Washington (A.D.T.); Neuropathology Service, Department of Pathology, Stanford University School of Medicine, Stanford, California (D.E.B.); Laboratory of Immunology, IRCCS San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy (B.C.); Case Western Reserve School of Medicine, Cleveland, Ohio (Y.K.); Neuroscience Associates, Boise, Idaho (T.C.M.).

Article

Publisher Item ID: nou161

DOI: 10.1093/neuonc/nou161

PubMed ID: 25140038

SO-VID: 8e9958fd-3314-4835-b29e-d31f0c96bde1

History

Keywords: glioma stem cells,invasion,malignancy,periostin,recurrent glioma

Data availability:

Keywords: glioma stem cells, invasion, malignancy, periostin, recurrent glioma

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