Abigail O. Smith:
ORCID: https://orcid.org/0000-0003-2765-8737
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Julie A. Jonassen: Role: InvestigationRole: Writing – review & editing
Kenley M. Preval:
ORCID: https://orcid.org/0000-0002-2425-0878
Role: InvestigationRole: Writing – review & editing
Roger J. Davis:
ORCID: https://orcid.org/0000-0002-0130-1652
Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: Writing – review
& editing
Gregory J. Pazour:
ORCID: https://orcid.org/0000-0002-6285-8796
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: SupervisionRole: Writing – original draftRole: Writing – review &
editing
David R. Beier: Role: Editor
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
28
December
2021
Publication date Collection:
December
2021
Volume: 17
Issue: 12
Electronic Location Identifier: e1009711
Affiliations
[1
]
Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech
II, Worcester, Massachusetts, United States of America
[2
]
Department of Microbiology and Physiological Systems, University of Massachusetts
Chan Medical School, Worcester Massachusetts, United States of America
Seattle Children’s Research Institute, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PGENETICS-D-21-00927
DOI: 10.1371/journal.pgen.1009711
PMC ID: 8746764
PubMed ID: 34962918
SO-VID: 8e6bfcc3-ea79-42ec-bf33-de8205690d2c
Copyright © © 2021 Smith et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/100000062, national institute of diabetes and digestive and kidney diseases;
Award ID: DK103632
Award Recipient
:
ORCID: https://orcid.org/0000-0002-6285-8796
Gregory J. Pazour
Funded by:
funder-id http://dx.doi.org/10.13039/100000062, national institute of diabetes and digestive and kidney diseases;
Award ID: DK107220
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0130-1652
Roger J. Davis
This work was supported by National Institute of Health (
www.nih.gov) grants DK103632 to G.J.P and DK107220 to R.J.D. The funders had no role in study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Signal transduction
Subject:
Cell signaling
Subject:
Signaling cascades
Subject:
c-Jun N-terminal kinase signaling cascade
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Fibrosis
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Weight Loss
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Post-Translational Modification
Subject:
Phosphorylation
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Genetic Diseases
Subject:
Autosomal Dominant Diseases
Subject:
Polycystic Kidney Disease
Subject:
Medicine and Health Sciences
Subject:
Clinical Genetics
Subject:
Genetic Diseases
Subject:
Autosomal Dominant Diseases
Subject:
Polycystic Kidney Disease
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Epithelial Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells