Gender-Affirming Hormone Therapy Modifies the CpG Methylation Pattern of the ESR1 Gene Promoter After Six Months of Treatment in Transmen.

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Abstract

Brain sexual differentiation is a process that results from the effects of sex steroids on the developing brain. Evidence shows that epigenetics plays a main role in the formation of enduring brain sex differences and that the estrogen receptor α (ESR1) is one of the implicated genes.

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Journal

Journal ID (iso-abbrev): J Sex Med

Title: The journal of sexual medicine

Publisher: Elsevier BV

ISSN (Electronic): 1743-6109

ISSN (Print): 1743-6095

Publication date (Electronic): September 2020

Volume: 17

Issue: 9

Affiliations

[1 ] Departamento de Psicología, Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da Coruña (UDC), Campus de Elviña, A Coruña, Spain; Instituto de Investigación Biomédica de A Coruña (INIBIC), CHUAC, SERGAS, A Coruña, Spain. Electronic address: rosa.fernandez@udc.es.

[2 ] Departamento de Psicología, Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da Coruña (UDC), Campus de Elviña, A Coruña, Spain; Instituto de Investigación Biomédica de A Coruña (INIBIC), CHUAC, SERGAS, A Coruña, Spain.

[3 ] Unidad de Identidad de Género, Instituto de Neurociencias, Hospital Clínic, I.D.I.B.A.P.S., Barcelona, Spain.

[4 ] Departmento de Endocrinología y Nutrición, Hospital Clínic, Barcelona, Spain.

[5 ] Servicio de Endocrinología y Nutrición, Unidad de Identidad de Género del Hospital Regional Universitario de Málaga, Málaga, Spain.

[6 ] Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Madrid, Spain.

Article

Publisher Item ID: S1743-6095(20)30668-8

DOI: 10.1016/j.jsxm.2020.05.027

PubMed ID: 32636163

SO-VID: 8e5b5e9a-57a3-430e-b28f-bb86a70c8120

History

Keywords: Gender Incongruence,RIII,Methylation,ESR1,ERα,Brain Masculinization

Data availability:

Keywords: Gender Incongruence, RIII, Methylation, ESR1, ERα, Brain Masculinization

Gender-Affirming Hormone Therapy Modifies the CpG Methylation Pattern of the ESR1 Gene Promoter After Six Months of Treatment in Transmen.

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Neuropharmacology and Therapy

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