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Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials
Hiddo J L Heerspink ,
Tom Greene ,
Hocine Tighiouart ,
Ron T Gansevoort ,
Josef Coresh ,
Andrew L Simon ,
Tak Mao Chan ,
Fan Fan Hou ,
Julia B Lewis ,
Francesco Locatelli ,
Manuel Praga ,
Francesco Paolo Schena ,
Andrew S Levey ,
Lesley A Inker ,
Angel Sevillano ,
Anne-Lise Kamper ,
Arjan D. van Zuilen ,
Barry M. Brenner ,
Bart Maes ,
Benno U. Ihle ,
Brendan Barret ,
CB Leung ,
CC Szeto ,
Christina Fitzner ,
Christoph Wanner ,
Claudio Pozzi ,
Claudio Ponticelli Montagnino ,
Di Xie ,
Dick de Zeeuw ,
Edmund Lewis ,
Eduardo Verde ,
Eduardo Gutierrez ,
Enyu Imai ,
Fan Fan Hou ,
Fernando Caravaca ,
Fernando C. Fervenza ,
Francesco Locatelli ,
Francesco Paolo Schena ,
Fumiaki Kobayashi ,
Gabriella Moroni ,
Gavin J. Becker ,
Gerald J. Beck ,
Gerald B. Appel ,
Gershon Frisch ,
GG van Essen ,
Giuseppe Maschio ,
Giuseppe Remuzzi ,
Giuseppe Montogrino ,
Hans-Henrik Parving ,
Hiddo J.L. Heerspink ,
Hirofumi Makino ,
Imitiaz Jehan ,
Jack F.M. Wetzels ,
James Donadio ,
Jamie Dwyer ,
Jan van den Brand ,
John Kusek ,
John M. Lachin ,
Jose Luño ,
Julia B. Lewis ,
Jürgen Floege ,
Kaleab Z. Abebe ,
KM Chow ,
Lawrence G. Hunsicker ,
Lucia del Vecchio ,
Manno Carlo ,
Manuel Praga ,
Marian Goicoechea ,
Maximilian von Eynatten ,
Neil Poulter ,
Nish Chaturvedi ,
Patrizia Passerini ,
Paul E. de Jong ,
Peter J. Blankestijn ,
Philip Li ,
Piero Ruggenenti ,
Pietro Zucchelli ,
Priscilla S. Kincaid-Smith ,
Ralf-Dieter Hilgers ,
Raymond O. Estacio ,
Richard D. Rohde ,
Ritsuko Katafuchi ,
Robert D. Toto ,
Robert W. Schrier ,
Roger A. Rodby ,
Ronald D. Perrone ,
Sadayoshi Ito ,
Saulo Klahr ,
Simeone Andrulli ,
Svend Strandgaard ,
Tak Mao Chan ,
Thierry P. Hannedouche ,
Thomas Rauen ,
Tom Greene ,
Ursula Verdalles ,
Vlado Perkovic ,
William Keane
January 2019
January 2019
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Abstract
Change in albuminuria has strong biological plausibility as a surrogate endpoint for
progression of chronic kidney disease, but empirical evidence to support its validity
is lacking. We aimed to determine the association between treatment effects on early
changes in albuminuria and treatment effects on clinical endpoints and surrograte
endpoints, to inform the use of albuminuria as a surrogate endpoint in future randomised
controlled trials.