Contributors
Alexandra C. Willcox:
ORCID: https://orcid.org/0000-0001-6037-6841
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: VisualizationRole: Writing – original draft
Kevin Sung: Role: Data curationRole: Formal analysisRole: MethodologyRole: SoftwareRole: ValidationRole:
VisualizationRole: Writing – review & editing
Meghan E. Garrett: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Jared G. Galloway: Role: Data curationRole: SoftwareRole: Writing – review & editing
Jesse H. Erasmus: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Jennifer K. Logue: Role: ResourcesRole: Writing – review & editing
David W. Hawman: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Helen Y. Chu: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Kim J. Hasenkrug: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Deborah H. Fuller: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Frederick A. Matsen IV: Role: Funding acquisitionRole: MethodologyRole: SupervisionRole: Writing – review
& editing
Julie Overbaugh:
ORCID: https://orcid.org/0000-0002-0239-9444
Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Shin-Ru Shih: Role: Editor
Journal
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
11
April
2022
Publication date Collection:
April
2022
Volume: 18
Issue: 4
Electronic Location Identifier: e1010155
Affiliations
[1
]
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington,
United States of America
[2
]
Medical Scientist Training Program, University of Washington, Seattle, Washington,
United States of America
[3
]
Molecular and Cellular Biology Program, University of Washington, Seattle, Washington,
United States of America
[4
]
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle,
Washington, United States of America
[5
]
Department of Microbiology, University of Washington, Seattle, Washington, United
States of America
[6
]
HDT Bio, Seattle, Washington, United States of America
[7
]
Department of Medicine, University of Washington, Seattle, Washington, United States
of America
[8
]
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy
and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United
States of America
[9
]
Laboratory of Persistent Viral Diseases, Division of Intramural Research, National
Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton,
Montana, United States of America
[10
]
Infectious Diseases and Translational Medicine, Washington National Primate Research
Center, Seattle, Washington, United States of America
[11
]
Center for Innate Immunity and Immune Disease, University of Washington, Seattle,
Washington, United States of America
Chang Gung University, TAIWAN
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: J.H.E. has equity interest in HDT Bio. J.H.E. is a consultant
for InBios. D.H.F. is a consultant for Gerson Lehrman Group, Orlance, Abacus Bioscience,
HDT Bio, Immusoft, and GE Global Health. J.H.E. is a co-inventor on U.S. patent application
no. 62/993,307 “Compositions and methods for delivery of RNA” pertaining to the LION
formulation. H.Y.C. reported consulting with Ellume, Pfizer, The Bill and Melinda
Gates Foundation, Glaxo Smith Kline, and Merck. She has received research funding
from Gates Ventures, Sanofi Pasteur, and support and reagents from Ellume and Cepheid
outside of the submitted work.
Author information
Article
Publisher ID:
PPATHOGENS-D-21-02407
DOI: 10.1371/journal.ppat.1010155
PMC ID: 9022802
PubMed ID: 35404959
SO-VID: 8d3b4b29-e15c-43ef-8bb4-519173fe7224
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
History
Date
received
: 30
November
2021
Date
accepted
: 21
March
2022
Page count
Figures: 5,
Tables: 1,
Pages: 22
Funding
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01 AI138709
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0239-9444
Julie Overbaugh
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01 AI146028
Award Recipient
:
Frederick A. Matsen IV
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: P51 OD010425-51
Award Recipient
:
Deborah H. Fuller
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: 27220140006C
Award Recipient
:
Jesse H. Erasmus
Funded by:
HDT Bio Corp
Award Recipient
:
Jesse H. Erasmus
Funded by:
funder-id http://dx.doi.org/10.13039/100006492, Division of Intramural Research, National Institute of Allergy and Infectious Diseases;
Award Recipient
:
Kim J. Hasenkrug
Funded by:
funder-id http://dx.doi.org/10.13039/100006492, Division of Intramural Research, National Institute of Allergy and Infectious Diseases;
Award Recipient
:
David W. Hawman
Funded by:
Howard Hughes Medical Institute and Simons Foundation
Award Recipient
:
Frederick A. Matsen IV
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: S10OD028685
This work was supported by NIH grants R01 AI138709 (awarded to J.O.) and R01 AI146028
(awarded to F.A.M. IV). Macaque studies were supported by NIH/ORIP center grant P51
OD010425-51 (WaNPRC, PI Sullivan, D.H.F. Co-I), a supplement to the NIH/NIAID Centers
for Excellence for Influenza Research and Surveillance contract 27220140006C (center
grant PI Richard Webby, supplement PI J.H.E.), and HDT Bio Corp internal funds (J.H.E.)
(Seattle, WA). Funding was partially provided by the Intramural Research Program of
the National Institute of Allergy and Infectious Diseases (D.W.H., K.J.H.). The research
of F.A.M. IV was supported in part by a Faculty Scholar grant from the Howard Hughes
Medical Institute and the Simons Foundation, and he is an investigator of the Howard
Hughes Medical Institute. Scientific Computing Infrastructure at Fred Hutch was funded
by NIH/ORIP grant S10OD028685. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
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Biology and life sciences
Subject:
Organisms
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Eukaryota
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Animals
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Amniotes
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Old World monkeys
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Macaque
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Biology and life sciences
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Animals
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Biology and life sciences
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Organisms
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Vertebrates
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Amniotes
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Mammals
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Primates
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Monkeys
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Old World monkeys
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Macaque
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Rhesus Monkeys
Subject:
Biology and life sciences
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Zoology
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Animals
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Vertebrates
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Amniotes
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Mammals
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Old World monkeys
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