Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting inflammation and the NLRP3 inflammasome: The role of the SIRT1/NF-κB pathway.

Wang, Zi-Kuan; Chen, Rui-Rui; Li, Jing-Hua; Chen, Jing-Yuan; Li, Wei; Niu, Xiao-Lin; Wang, Fang-Fang; WANG, Jing; Yang, Jing-Xiao

doi:10.1016/j.intimp.2020.107086

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Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting inflammation and the NLRP3 inflammasome: The role of the SIRT1/NF-κB pathway.

Author(s): Zi-Kuan Wang ¹ , Rui-Rui Chen ¹ , Jing-Hua Li ¹ , Jing-Yuan Chen ² , Wei Li ¹ , Xiao-Lin Niu ¹ , Fang-Fang Wang ¹ , Jing Wang ¹ , Jing-Xiao Yang ³

Publication date (Electronic): Dec 2020

Journal: International immunopharmacology

Publisher: Elsevier BV

Keywords: Inflammatory response, Myocardial ischemia/reperfusion, NLRP3 inflammasome, Puerarin, SIRT1/NF-κB pathway

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Abstract

The purpose of this study was to investigate the protective effects of puerarin and elucidate the underlying mechanisms of puerarin in myocardial ischemia/reperfusion (MI/R) injury.

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Journal ID (iso-abbrev): Int Immunopharmacol

Title: International immunopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1878-1705

ISSN (Print): 1567-5769

Publication date (Electronic): Dec 2020

Volume: 89

Issue: Pt B

Affiliations

[1 ] Department of Cardiology, Tangdu Hospital, Air Force Medical University, Xi'an 710000, China.

[2 ] Department of the Second Outpatient, Air Force 986 Hospital, Xi'an 710025, China.

[3 ] Department of Cardiology, Tangdu Hospital, Air Force Medical University, Xi'an 710000, China. Electronic address: yangjingxiaowby@163.com.

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Publisher Item ID: S1567-5769(20)31894-4

DOI: 10.1016/j.intimp.2020.107086

PubMed ID: 33068868

SO-VID: 8cafb4ca-a9be-41a4-b6fb-3c1f4fe18bac

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Keywords: Inflammatory response,Myocardial ischemia/reperfusion,NLRP3 inflammasome,Puerarin,SIRT1/NF-κB pathway

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Keywords: Inflammatory response, Myocardial ischemia/reperfusion, NLRP3 inflammasome, Puerarin, SIRT1/NF-κB pathway

Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting inflammation and the NLRP3 inflammasome: The role of the SIRT1/NF-κB pathway.

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