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      Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

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          Abstract

          Benralizumab is a humanised, afucosylated, anti-interleukin-5 receptor α monoclonal antibody that induces direct, rapid, and nearly complete depletion of eosinophils. We aimed to assess the efficacy and safety of benralizumab as add-on therapy for patients with severe, uncontrolled asthma and elevated blood eosinophil counts.

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          Author and article information

          Journal
          The Lancet
          The Lancet
          Elsevier BV
          01406736
          October 2016
          October 2016
          : 388
          : 10056
          : 2128-2141
          Article
          10.1016/S0140-6736(16)31322-8
          27609406
          8ca42148-d7d7-44c8-a5bf-bfadc962b7b3
          © 2016

          http://www.elsevier.com/tdm/userlicense/1.0/

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