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      Human dendritic cell subsets: An updated view of their ontogeny and functional specialization

      review-article
      Author(s): 1 ,
      Publication date (Electronic):
      Journal: European Journal of Immunology
      Publisher: John Wiley and Sons Inc.
      Keywords: Human, dendritic cell, subsets

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          Abstract

          Human DCs have been divided into several subsets based on their phenotype and ontogeny. Recent high throughput single‐cell methods have revealed additional heterogeneity within human DC subsets, and new subpopulations have been proposed. In this review, we provide an updated view of the human DC subsets and of their ontogeny supported by recent clinical studies . We also summarize their main characteristics including their functional specialization.

          Abstract

          We provide an updated view of the human dendritic cell subsets and of their ontogeny. We also summarize their main characteristics including their functional specialization.

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          Most cited references99

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          Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

          Alexandra-Chloe Villani, Rahul Satija, Gary Reynolds … (2017)
          Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and antigen presentation and consist of multiple specialized subtypes. However, their identities and interrelationships are not fully understood. Using unbiased single-cell RNA sequencing (RNA-seq) of ~2400 cells, we identified six human DCs and four monocyte subtypes in human blood. Our study reveals a new DC subset that shares properties with plasmacytoid DCs (pDCs) but potently activates T cells, thus redefining pDCs; a new subdivision within the CD1C+ subset of DCs; the relationship between blastic plasmacytoid DC neoplasia cells and healthy DCs; and circulating progenitor of conventional DCs (cDCs). Our revised taxonomy will enable more accurate functional and developmental analyses as well as immune monitoring in health and disease.
          Article 0 comments Cited 662 times – based on 0 reviews     Review now
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            Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

            Yonit Lavin, Soma Kobayashi, Andrew Leader … (2017)
            To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune changes. Utilizing a barcoding method that allows a simultaneous single cell analysis of the tumor, non-involved lung and blood cells together with multiplex tissue imaging to assess spatial cell distribution, we provide a detailed immune cell atlas of early lung tumors. We show that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell compartments. Moreover, we identified changes in tumor infiltrating myeloid cell (TIM) subsets that likely compromise anti-tumor T cell immunity. Paired single cell analyses thus offer valuable knowledge of tumor-driven immune changes, providing a powerful tool for the rational design of immune therapies. Comparing single tumor cells with adjacent normal tissue and blood from patients with lung adenocarcinoma charts early changes in tumor immunity and provides insights to guide immunotherapy design.
            Article 0 comments Cited 599 times – based on 0 reviews     Review now
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              Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

              Rapolas Zilionis, Camilla Engblom, Christina Pfirschke … (2019)
              Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells and neutrophils, and have emerged as key regulators of cancer growth. These cells can diversify into a spectrum of states, which may promote or limit tumor outgrowth, but remain poorly understood. Here, we used single-cell RNA sequencing to map TIMs in non-small cell lung cancer patients. We uncovered 25 TIM states, most of which were reproducibly found across patients. To facilitate translational research of these populations, we also profiled TIMs in mice. In comparing TIMs across species, we identified a near-complete congruence of population structures among dendritic cells and monocytes; conserved neutrophil subsets; and species differences among macrophages. By contrast, myeloid cell population structures in patients’ blood showed limited overlap with those of TIMs. This study determines the lung TIM landscape and sets the stage for future investigations into the potential of TIMs as immunotherapy targets. Tumor-infiltrating myeloid cells (TIM) have emerged as key cancer regulators and potential next-generation immunotherapy targets, yet they remain incompletely understood. Using single cell RNA-seq, Zilionis et al. map the TIM landscape in human and murine lung tumors and systematically compare cell states, revealing conserved myeloid populations across individuals and species.
              Article 0 comments Cited 549 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Elodie Segura:
                ORCID: https://orcid.org/0000-0003-1795-1921
                elodie.segura@curie.fr
                Journal
                Journal ID (nlm-ta): Eur J Immunol
                Journal ID (iso-abbrev): Eur J Immunol
                Journal ID (doi): 10.1002/(ISSN)1521-4141
                Journal ID (publisher-id): EJI
                Title: European Journal of Immunology
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Print): 0014-2980
                ISSN (Electronic): 1521-4141
                Publication date (Electronic): 11 March 2022
                Publication date (Print): November 2022
                Volume: 52
                Issue: 11 ( doiID: 10.1002/eji.v52.11 )
                Pages: 1759-1767
                Affiliations
                [ 1 ] Institut Curie PSL Research University Paris France
                Author notes
                [*] [* ] Full correspondence : Elodie Segura, Institut Curie, PSL Research University, INSERM, U932, 26 rue d'Ulm, 75005 Paris, France.

                Email: elodie.segura@ 123456curie.fr

                Author information
                https://orcid.org/0000-0003-1795-1921
                Article
                Publisher ID: EJI5246
                DOI: 10.1002/eji.202149632
                PMC ID: 9790408
                PubMed ID: 35187651
                SO-VID: 8c8390b0-3ffe-46c4-a97d-c70b38027954
                Copyright © © 2022 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                Date revision received : 13 January 2022
                Date received : 26 October 2021
                Date accepted : 03 February 2022
                Page count
                Figures: 2, Tables: 2, Pages: 9, Words: 6650
                Categories
                Subject: Review|Clinical
                Subject: Highlights
                Subject: Reviews
                Subject: Clinical
                Custom metadata
                source-schema-version-number 2.0
                cover-date November 2022
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.2.3 mode:remove_FC converted:25.12.2022

                ScienceOpen disciplines: Immunology
                Keywords: human,dendritic cell,subsets
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: human, dendritic cell, subsets

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