Study of physiochemical properties of trisubstituted pyrazole derivatives using polar aprotic solvents

Abstract

Pyrazole derivatives are aromatic heterocyclic compounds endowed with multifaceted applications. In the present study 1,3,4-trisubstituted pyrazoles derivatives have been synthesized for the purpose of studying their physical properties and their characterization was done by FTIR, ¹H NMR and ¹³C NMR spectroscopic technique. The measurement of densities ( ρ) and viscosities ( η) of solutions of substituted pyrazole derivative in polar aprotic solvent i.e., Dimethyl sulfoxide (DMSO), nitromethane (NM) as well as in their 1:1 binary mixture (DMSO + NM) was done at 310 K over a wide range of solute concentration (5–100) × 10 ^–4 mol dm ⁻³. The experimental results were used to determine the excess molar volumes \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt}

$$\begin{document}$$({V}_{m}^{E})$$\end{document}$$ . The data of density–viscosity revealed the dipole–dipole interactions occurred between the pyrazole derivative (solute) and the solvent (DMSO, NM). Excess molar studies \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} $$\begin{document}$$({V}_{m}^{E})$$\end{document}$$ revealed that solute–solvent interaction was found to be stronger in case of nitromethane solvent.