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      Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis.

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          Abstract

          HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether HSPA8 SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the HSPA8 gene using probe-based PCR. SNP rs10892958 of HSPA8 was associated with an increased risk (risk allele G) of IS in smokers (OR = 1.37; 95% CI = 1.07-1.77; p = 0.01) and patients with low fruit and vegetable consumption (OR = 1.36; 95% CI = 1.14-1.63; p = 0.002). SNP rs1136141 of HSPA8 was also associated with an increased risk of IS (risk allele A) exclusively in smokers (OR = 1.68; 95% CI = 1.23-2.28; p = 0.0007) and in patients with a low fruit and vegetable intake (OR = 1.29; 95% CI = 1.05-1.60; p = 0.04). Sex-stratified analysis revealed an association of rs10892958 HSPA8 with an increased risk of IS in males (risk allele G; OR = 1.30; 95% CI = 1.05-1.61; p = 0.01). Thus, SNPs rs10892958 and rs1136141 in the HSPA8 gene represent novel genetic markers of IS.

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          Author and article information

          Journal
          Genes (Basel)
          Genes
          MDPI AG
          2073-4425
          2073-4425
          May 27 2023
          : 14
          : 6
          Affiliations
          [1 ] Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
          [2 ] Laboratory of Statistical Genetics and Bioinformatics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
          [3 ] Laboratory of Genome Editing for Biomedicine and Animal Health, Belgorod State National Research University, 308015 Belgorod, Russia.
          [4 ] Department of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia.
          [5 ] Department of Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, UK.
          [6 ] Laboratory of Population Genetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia.
          [7 ] Department of Medical Biological Disciplines, Belgorod State University, 308015 Belgorod, Russia.
          [8 ] Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041 Kursk, Russia.
          Article
          genes14061171
          10.3390/genes14061171
          10298525
          37372351
          8bb061b4-663c-4c6c-8125-280e37f1bbda
          History

          rs10892958,ischemic stroke,heat shock proteins,gene-environmental interaction,fruit and vegetable intake,chaperones,HSPA8,HSC70,smoking,rs1136141

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