Microplastics from agricultural plastic mulch films: A mini-review of their impacts on the animal reproductive system.

Abstract

Plastic mulch films (PMFs) are widely used to improve crop quality and quantity. Although they provide a range of benefits, they degrade into widespread microplastics (MPs), which can cause an unavoidable risk of environmental problems. The residue of PMFs is a significant source of MPs in soils, which can then spread into various ecosystems and be easily absorbed by organisms due to their small size, and subsequently transported through food chain. Notably, MPs have been found in the human placenta, stool and blood, raising an urgent reminder of the potential dangers of MPs to human health. This review summarizes recent studies concerning the effects of MPs on the reproductive system in soil invertebrates, aquatic animals and rodents of both sexes and the mechanisms by which MPs affect the animal reproductive system. The studies on females demonstrated that MPs decrease oocyte quantity and quality, and induce ovary fibrosis, pyroptosis and apoptosis of granulosa cells. In addition, disrupted integrity of the blood-testis barrier, damaged spermatogenesis and compromised sperm quality have been shown in most studies on male animals. The studies on the mechanisms of these effects have provided evidence that MPs act on the animal reproductive system through reactive oxygen species-related mechanisms by initiating the Wnt/β-Catenin and NLRP3/Caspase-1 pathways in females, and the Nrf2/HO-1/NF-κB, p38 MAPK and MAPK/Nrf2 pathways in males. Taken together, these studies reveal the reproductive toxicity of MPs from PMF on animals and serve as a reminder to properly dispose of PMF waste.