Evaluation of dabigatran, rivaroxaban and apixaban target-specific assays in a multicenter French study.

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Abstract

Dabigatran etexilate, rivaroxaban and apixaban (DOACs) are widely used and measurement of their concentration is desirable in certain clinical situations. Target-specific assays are available but limited information exists on their performance especially in their ability to accurately measure low and high concentrations.

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Author and article information

Journal

Journal ID (iso-abbrev): Thromb Res

Title: Thrombosis research

Publisher: Elsevier BV

ISSN (Electronic): 1879-2472

ISSN (Print): 0049-3848

Publication date (Electronic): Oct 2017

Volume: 158

Affiliations

[1 ] INSERM UMR_S1140, Faculté de Pharmacie, Paris, France; Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Rennes, France. Electronic address: isabelle.gouin@chu-rennes.fr.

[2 ] Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Bordeaux, France.

[3 ] Unité d'Hémostase, Centre Hospitalier Universitaire, Dijon, France.

[4 ] Hémostase et transfusion, Centre Hospitalier Universitaire, Lille, France; UMR_S1011, Faculté de Médecine Pôle Recherche, Université de Lille Nord de France, Lille, France.

[5 ] Laboratoire de Pharmacologie -Toxicologie, Centre Hospitalier Universitaire, Saint-Etienne, France; Groupe de Recherche sur la Thrombose, Université Jean Monnet, Saint-Etienne, France.

[6 ] Biostatistics, AP-HP, Pitié-Salpêtriere University Hospital, Paris, France.

[7 ] Hematologie-Hemostase, Centre Hospitalier Universitaire, Tours, France.

[8 ] Hematology Laboratory, Toulouse University Hospital, Toulouse, France.

Article

Publisher Item ID: S0049-3848(17)30479-6

DOI: 10.1016/j.thromres.2017.09.001

PubMed ID: 28892657

SO-VID: 8a2fd24d-3643-4386-b8e5-591e8692796d

History

Keywords: Anti-Xa activity,DOAC measurement,Dilute thrombin time,Direct factor Xa inhibitor,Direct thrombin inhibitor,Ecarin assay,PT,aPTT

Data availability:

Keywords: Anti-Xa activity, DOAC measurement, Dilute thrombin time, Direct factor Xa inhibitor, Direct thrombin inhibitor, Ecarin assay, PT, aPTT

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