Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network.

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Abstract

Astrocytes senescence has been demonstrated in the aging brain and Alzheimer's disease (AD). Moreover, lower glucose metabolism has been confirmed in the early stage of AD. However, whether low glucose could induce astrocytes senescence remain ambiguous. Studies have shown that the ethanol extracts of Scutellaria baicalensis Georgi (SGE) exert neuroprotective and anti-aging effects, while whether SGE could delay astrocytes senescence was unclear.

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Author and article information

Journal

Journal ID (iso-abbrev): Phytomedicine

Title: Phytomedicine : international journal of phytotherapy and phytopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1618-095X

ISSN (Print): 0944-7113

Publication date (Electronic): Feb 12 2022

Volume: 99

Affiliations

[1 ] Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, China; Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan, China. Electronic address: gaoli87@sxu.edu.cn.

[2 ] Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, China; Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan, China.

[3 ] Complex Systems Research Center, Shanxi University, Taiyuan, China.

[4 ] Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: dugh@imm.ac.cn.

Article

Publisher Item ID: S0944-7113(22)00068-X

DOI: 10.1016/j.phymed.2022.153990

PubMed ID: 35202958

SO-VID: 89a37e31-4e0e-46b0-9742-926aef918e92

History

Keywords: Boolean network,SGE,SASP,CXCL10,Astrocytes senescence

Data availability:

Keywords: Boolean network, SGE, SASP, CXCL10, Astrocytes senescence

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