For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
4
views
61
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
3 collections
    0
    shares
      350
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found

      Challenges and Management of Long COVID in Individuals with Hematological Illnesses

      review-article
      Author(s): a , b , * , a , b , c
      Publication date (Electronic):
      Journal: Acta Haematologica
      Publisher: S. Karger AG
      Keywords: COVID-19, Long COVID, Rehabilitation, Persistent symptoms

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          COVID-19 has impacted hundreds of millions of people globally, a relatively large proportion of whom continue to suffer from ongoing, sometime debilitating symptoms. This phenomenon, termed “long COVID,” is difficult to diagnose and manage because of a paucity of objective findings and despite the abundance of descriptive data published so far. In this review, we aimed to describe the common manifestations of long COVID, diagnostic and management challenges, and address specific aspects in hematologic patients.

          Related collections

          Most cited references61

          • Record: found
          • Abstract: found
          • Article: found

          Attributes and predictors of long COVID

          Carole H. Sudre, Benjamin Murray, Thomas Varsavsky … (2021)
          Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app1. A total of 558 (13.3%) participants reported symptoms lasting ≥28 days, 189 (4.5%) for ≥8 weeks and 95 (2.3%) for ≥12 weeks. Long COVID was characterized by symptoms of fatigue, headache, dyspnea and anosmia and was more likely with increasing age and body mass index and female sex. Experiencing more than five symptoms during the first week of illness was associated with long COVID (odds ratio = 3.53 (2.76-4.50)). A simple model to distinguish between short COVID and long COVID at 7 days (total sample size, n = 2,149) showed an area under the curve of the receiver operating characteristic curve of 76%, with replication in an independent sample of 2,472 individuals who were positive for severe acute respiratory syndrome coronavirus 2. This model could be used to identify individuals at risk of long COVID for trials of prevention or treatment and to plan education and rehabilitation services.
          Article 0 comments Cited 1037 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found

            Hematological findings and complications of COVID ‐19

            Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Ismail Elalamy … (2020)
            Abstract COVID‐19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Lymphopenia may be considered as a cardinal laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases. During the disease course, longitudinal evaluation of lymphocyte count dynamics and inflammatory indices, including LDH, CRP and IL‐6 may help to identify cases with dismal prognosis and prompt intervention in order to improve outcomes. Biomarkers, such high serum procalcitonin and ferritin have also emerged as poor prognostic factors. Furthermore, blood hypercoagulability is common among hospitalized COVID‐19 patients. Elevated D‐Dimer levels are consistently reported, whereas their gradual increase during disease course is particularly associated with disease worsening. Other coagulation abnormalities such as PT and aPTT prolongation, fibrin degradation products increase, with severe thrombocytopenia lead to life‐threatening disseminated intravascular coagulation (DIC), which necessitates continuous vigilance and prompt intervention. So, COVID‐19 infected patients, whether hospitalized or ambulatory, are at high risk for venous thromboembolism, and an early and prolonged pharmacological thromboprophylaxis with low molecular weight heparin is highly recommended. Last but not least, the need for assuring blood donations during the pandemic is also highlighted.
            Article 0 comments Cited 796 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Long covid—mechanisms, risk factors, and management

              Harry Crook, Sanara Raza, Joseph Nowell … (2021)
              Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on the lives and health of people around the globe. As of 4 July 2021, more than 183 million confirmed cases of covid-19 had been recorded worldwide, and 3.97 million deaths. Recent evidence has shown that a range of persistent symptoms can remain long after the acute SARS-CoV-2 infection, and this condition is now coined long covid by recognized research institutes. Studies have shown that long covid can affect the whole spectrum of people with covid-19, from those with very mild acute disease to the most severe forms. Like acute covid-19, long covid can involve multiple organs and can affect many systems including, but not limited to, the respiratory, cardiovascular, neurological, gastrointestinal, and musculoskeletal systems. The symptoms of long covid include fatigue, dyspnea, cardiac abnormalities, cognitive impairment, sleep disturbances, symptoms of post-traumatic stress disorder, muscle pain, concentration problems, and headache. This review summarizes studies of the long term effects of covid-19 in hospitalized and non-hospitalized patients and describes the persistent symptoms they endure. Risk factors for acute covid-19 and long covid and possible therapeutic options are also discussed.
              Article 0 comments Cited 677 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Acta Haematol
                Journal ID (iso-abbrev): Acta Haematol
                Journal ID (publisher-id): AHA
                Title: Acta Haematologica
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.com )
                ISSN (Print): 0001-5792
                ISSN (Electronic): 1421-9662
                Publication date (Electronic): 8 February 2022
                Publication date PMC-release: 8 February 2022
                Pages: 1-7
                Affiliations
                [1] aCOVID Recovery Clinic, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
                [2] bFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel
                [3] cInfectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
                Author notes
                Article
                Publisher ID: aha-0001
                DOI: 10.1159/000522437
                PMC ID: 9059010
                PubMed ID: 35134812
                SO-VID: 89596135-6e67-46a3-95ba-3d42a3ce2b23
                Copyright © Copyright © 2022 by S. Karger AG, Basel
                License:

                This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

                History
                Date received : 25 November 2021
                Date accepted : 1 February 2022
                Page count
                Figures: 1, Tables: 1, References: 48, Pages: 7
                Categories
                Subject: Review

                Keywords: covid-19,long covid,rehabilitation,persistent symptoms
                Data availability:
                Keywords: covid-19, long covid, rehabilitation, persistent symptoms

                Comments

                Comment on this article

                scite_

                Similar content350

                See all similar

                Cited by1

                See all cited by

                Most referenced authors1,202

                See all reference authors