Safety and efficacy of flecainide associated with beta-blockers in arrhythmogenic right ventricular cardiomyopathy.

Author(s): Thomas Rolland ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Nicolas Badenco ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Carole Maupain ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Guillaume Duthoit ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Xavier Waintraub ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Mikael Laredo ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Caroline Himbert ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Robert Frank ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Francoise Hidden-Lucet ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Estelle Gandjbakhch ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶

Publication date (Electronic): February 02 2022

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Publisher: Oxford University Press (OUP)

Keywords: Antiarrhythmic drugs, Arrhythmogenic right ventricular cardiomyopathy/dysplasia, Beta-blockers, Cardiomyopathy, Flecainide, Ventricular tachycardia

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Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy associated with a high risk of ventricular arrhythmia (VA). Current guidelines recommend beta-blockers as first-line medical therapy and if ineffective, sotalol or amiodarone. We describe our experience, as a tertiary centre for ARVC, with the effectiveness and tolerance of flecainide in addition to beta-blockers to prevent VA in ARVC.

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Journal ID (iso-abbrev): Europace

Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1532-2092

ISSN (Print): 1099-5129

Publication date (Electronic): February 02 2022

Volume: 24

Issue: 2

Affiliations

[1 ] Sorbonne Universités, UPMC Univ Paris 06, Paris, France.

[2 ] APHP, Pitié-Salpêtriére University Hospital, Institute of Cardiology, Paris, France.

[3 ] Centre de Référence des Maladies Cardiaques Héréditaires, Paris, France.

[4 ] Action Coeur Study Groupe, Paris, France.

[5 ] Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.

[6 ] APHP, Pitié-Salpêtriére University Hospital, Department of Genetics, Paris, France.

Article

Publisher Item ID: 6359546

DOI: 10.1093/europace/euab182

PubMed ID: 34459901

SO-VID: 89554a64-7ca0-4b2c-a497-bbcb1562cf0a

History

Keywords: Arrhythmogenic right ventricular cardiomyopathy/dysplasia,Cardiomyopathy,Beta-blockers,Antiarrhythmic drugs,Flecainide,Ventricular tachycardia

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Keywords: Arrhythmogenic right ventricular cardiomyopathy/dysplasia, Cardiomyopathy, Beta-blockers, Antiarrhythmic drugs, Flecainide, Ventricular tachycardia

Safety and efficacy of flecainide associated with beta-blockers in arrhythmogenic right ventricular cardiomyopathy.

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