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      Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis (JCOG0106).

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          Abstract

          Owing to the risks of serious and sustained toxicity, anticancer drugs such as cisplatin and irinotecan cannot be readily administered to patients with gastric cancer and severe peritoneal metastasis. Therefore, a standard chemotherapy regimen has yet to be established for these types of patients. This randomized study investigated the utility of sequential methotrexate and 5-fluorouracil therapy vs. 5-fluorouracil continuous infusion for gastric cancer with peritoneal metastasis.

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          Author and article information

          Journal
          Jpn J Clin Oncol
          Japanese journal of clinical oncology
          Oxford University Press (OUP)
          1465-3621
          0368-2811
          Oct 2013
          : 43
          : 10
          Affiliations
          [1 ] *Department of Medical Oncology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu City, Oita 879-5593, Japan. kshirao@oita-u.ac.jp.
          Article
          hyt114
          10.1093/jjco/hyt114
          24014884
          892689b3-dc7e-4ded-8a2a-795f5eb5cc82
          History

          Phase III study,chemotherapy,gastric cancer,peritoneal metastasis

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