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      Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections

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          Abstract

          Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30 days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90 days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures.

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          Author and article information

          Journal
          Clin Infect Dis
          Clin. Infect. Dis
          cid
          cid
          Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
          Oxford University Press
          1058-4838
          1537-6591
          15 December 2016
          13 September 2016
          15 December 2017
          : 63
          : 12
          : 1615-1618
          Affiliations
          [1 ] Department of Medicine
          [2 ] Department of Pharmacy and Therapeutics, University of Pittsburgh
          [3 ] Antibiotic Management Program
          [4 ] XDR Pathogen Laboratory, University of Pittsburgh Medical Center
          [5 ] VA Pittsburgh Healthcare System, Pennsylvania
          [6 ] Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University , Newark
          Author notes
          [a]

          Both authors contributed equally to this work.

          Correspondence: C. J. Clancy, Associate Professor of Medicine, University of Pittsburgh, 3550 Terrace St, S867 Scaife Hall, Pittsburgh, PA 15261 ( cjc76@ 123456pitt.edu ).
          Article
          PMC5146720 PMC5146720 5146720 ciw636
          10.1093/cid/ciw636
          5146720
          27624958
          8914cf38-f643-4eff-bd45-23e9c8ca30f6
          © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
          History
          : 17 May 2016
          : 14 August 2016
          Funding
          Funded by: XDR Pathogen Laboratory by the University of Pittsburgh Medical Center;
          Funded by: NIH;
          Award ID: K08AI114883
          Award ID: R21AI117338
          Award ID: R01AI090155
          Award ID: R21AI111037
          Categories
          Brief Reports

          Klebsiella pneumoniae carbapenemase,carbapenem-resistant Enterobacteriaceae,ceftazidime-avibactam resistance

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