<i>Ageratina adenophora</i> Inhibits Spleen Immune Function in Rats via the Loss of the FRC Network and Th1–Th2 Cell Ratio Elevation

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Abstract

The objective of this study was to determine the impact of Ageratina adenophora (A. adenophora) on splenic immune function in a rat model. Rats were fed with 10 g/100 g normal feed and an experimental feed, which was composed of 3:7 A. adenophora powder and normal feed for 60 days. On days 14, 28, and 60, subsets of rats ( n = 8 rats/group/time point) were selected for blood and spleen tissue sample collection. The results showed that the proportion of CD3 ⁺ T cells in the spleen was decreased at day 60 (vs. control). Also, mRNA and protein expression of chemokines CCL21 and CCL19 and functional protein gp38 in spleen decreased significantly versus the control at day 60. In addition, ER-TR7 antigen protein expression was also decreased at day 60. Levels of T-helper (Th)1 cells significantly increased, whereas those of Th2 cells decreased significantly versus the control at day 60 in spleen. The finding revealed that A. adenophora could affect splenic immune function in rats by altering the fibroblast reticulocyte (FRC) network, as well as by causing an imbalance in Th1/Th2 cell ratios. This research provides new insights into potential mechanisms of spleen immunotoxicity due to exposures to A. Adenophora.

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Journal ID (nlm-ta): Toxins (Basel)

Journal ID (iso-abbrev): Toxins (Basel)

Journal ID (publisher-id): toxins

Title: Toxins

Publisher: MDPI

ISSN (Electronic): 2072-6651

Publication date (Electronic): 26 April 2021

Publication date Collection: May 2021

Volume: 13

Issue: 5

Electronic Location Identifier: 309

Affiliations

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China; zhihua_ren@ 123456126.com (Z.R.); gaopeijune@ 123456163.com (P.G.); samuel20okyere@ 123456gmail.com (S.K.O.); yjchoi@ 123456163.com (Y.C.); juanwen881010@ 123456163.com (J.W.); jingbooo@ 123456163.com (B.J.); dengjl213@ 123456126.com (J.D.)

Author notes

[* ]Correspondence: hychun114@ 123456163.com ; Tel.: +86-28-8629-1162

[†]

Authors contributed equally to this paper and should be considered as first co-authors.

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Samuel Kumi Okyere https://orcid.org/0000-0003-4820-8620

Yanchun Hu https://orcid.org/0000-0002-2998-7879

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Publisher ID: toxins-13-00309

DOI: 10.3390/toxins13050309

PMC ID: 8145992

PubMed ID: 33926136

SO-VID: 88f8a699-bb96-4291-bed2-1a4e43ad1510

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

Ageratina adenophora Inhibits Spleen Immune Function in Rats via the Loss of the FRC Network and Th1–Th2 Cell Ratio Elevation

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Bacterial extracellular vesicles

Most cited references 45

Differentiation of effector CD4 T cell populations (*).

Inflammasome Complexes: Emerging Mechanisms and Effector Functions.

Signaling in innate immunity and inflammation.

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