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C2K77 ELISA detects cleavage of type II collagen by cathepsin K in equine articular cartilage
December 2017
December 2017
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Abstract
Develop a species-specific ELISA for a neo-epitope generated by cathepsin K cleavage
of equine type II collagen to: (1) measure cartilage type II collagen degradation
by cathepsin K in vitro, (2) identify cytokines that upregulate cathepsin K expression
and (3) compare cathepsin K with matrix metalloproteinase (MMP) collagenase activity
in stimulated cartilage explants and freshly isolated normal and osteoarthritic (OA)
articular cartilages.