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      UK guidelines on oesophageal dilatation in clinical practice

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          Abstract

          These are updated guidelines which supersede the original version published in 2004. This work has been endorsed by the Clinical Services and Standards Committee of the British Society of Gastroenterology (BSG) under the auspices of the oesophageal section of the BSG. The original guidelines have undergone extensive revision by the 16 members of the Guideline Development Group with representation from individuals across all relevant disciplines, including the Heartburn Cancer UK charity, a nursing representative and a patient representative. The methodological rigour and transparency of the guideline development processes were appraised using the revised Appraisal of Guidelines for Research and Evaluation (AGREE II) tool.

          Dilatation of the oesophagus is a relatively high-risk intervention, and is required by an increasing range of disease states. Moreover, there is scarcity of evidence in the literature to guide clinicians on how to safely perform this procedure. These guidelines deal specifically with the dilatation procedure using balloon or bougie devices as a primary treatment strategy for non-malignant narrowing of the oesophagus. The use of stents is outside the remit of this paper; however, for cases of dilatation failure, alternative techniques—including stents—will be listed. The guideline is divided into the following subheadings: (1) patient preparation; (2) the dilatation procedure; (3) aftercare and (4) disease-specific considerations. A systematic literature search was performed. The Grading of Recommendations Assessment, Develop­ment and Evaluation (GRADE) tool was used to evaluate the quality of evidence and decide on the strength of recommendations made.

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          Management of antithrombotic agents for endoscopic procedures.

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            The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection.

            Use of endoscopic submucosal dissection (ESD) for management of widespread superficial esophageal carcinomas may be complicated by the development of severe strictures, which may require serial treatment with endoscopic balloon dilatation (EBD). The goal of this study was to determine the efficacy of endoscopic triamcinolone injection (ETI) for the prevention of stricture formation after ESD. Case series. Tertiary-care referral center. A total of 41 consecutive patients who had a semi-circumferential mucosal defect that arose after ESD for superficial esophageal squamous cell carcinomas were enrolled in this study. EBD and ETI. Incidence of stricture and frequency of required EBD. ETI was performed in one group of patients (study group, n = 21) but not in the other (control group, n = 20). The incidence of stricture was significantly lower in the study group (19.0%) than in the control group (75.0%; P < .001). The number of required EBDs was also lower in the study group (mean, 1.7; range, 0-15) than in the control group (mean, 6.6; range 0-20). There were no side effects or complications associated with ETI. Nonrandomized study design and small number of patients in a single endoscopic center. This study suggests that ETI is safe and effective for the prevention of esophageal stricture in patients undergoing ESD for superficial esophageal squamous cell carcinomas. Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
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              Usefulness of oral prednisolone in the treatment of esophageal stricture after endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma.

              Endoscopic submucosal dissection (ESD) permits en bloc removal of superficial esophageal squamous cell carcinoma. However, postprocedure stricture is common after ESD for extensive tumors, and multiple endoscopic balloon dilation (EBD) is required for recalcitrant cases. To evaluate the effectiveness of oral prednisolone in controlling postprocedure esophageal stricture. Retrospective study. Endoscopy department at a university hospital. Patients who underwent complete circular or semicircular ESD for esophageal squamous cell carcinoma involving more than three fourths of the lumen were treated with either pre-emptive EBD or oral prednisolone. Preemptive EBD was started on the third day post-ESD and continued twice weekly for 8 weeks. Oral prednisolone was started at 30 mg/day on the third day post-ESD , tapered gradually, and then discontinued 8 weeks later. An additional EBD was performed on demand in both groups whenever dysphagia appeared. The incidence of esophageal stricture and number of EBD sessions required to relieve dysphagia. Stricture at 3 months after ESD was found in 7 of 22 patients in the preemptive EBD group but only 1 of 19 in the oral prednisolone group (P < .05). The average number of EBD sessions required was 15.6 in the preemptive EBD group and 1.7 in the oral prednisolone group (P < .0001). After complete circular ESD, 32.7 EBD sessions were needed on average in the preemptive EBD group, whereas fewer were needed in the oral prednisolone group (P < .05). Nonrandomized study. Post-ESD esophageal strictures were persistent even if treated preemptively with multiple EBD sessions, but oral prednisolone may offer a useful preventive option. Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
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                Author and article information

                Journal
                Gut
                Gut
                gutjnl
                gut
                Gut
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                0017-5749
                1468-3288
                June 2018
                24 February 2018
                : 67
                : 6
                : 1000-1023
                Affiliations
                [1 ] departmentDivision of Gastroenterology and Hepatology , Mayo Clinic , Rochester, Minnesota, USA
                [2 ] departmentCancer Biomarker Group, Swansea Medical School , Swansea University , Swansea, UK
                [3 ] departmentDepartment of GI Sciences , University of Manchester , Manchester, UK
                [4 ] Salford Royal NHS Foundation Trust , Salford, UK
                [5 ] departmentDepartment of Gastroenterology , Southampton University Hospital , Southampton, UK
                [6 ] departmentDepartment of Gastroenterology , Portsmouth University Hospitals NHS Trust , Portsmouth, UK
                [7 ] departmentDigestive Diseases Centre , University Hospitals of Leicester , Leicester, UK
                [8 ] departmentDepartment of Gastroenterology , Wye Valley NHS Trust , Wye Valley, UK
                [9 ] departmentDepartment of Gastroenterology , University College Hospital , London, UK
                [10 ] departmentDepartment of Radiology , The Christie NHS Foundation Trust , Manchester, UK
                [11 ] departmentDepartment of Gastroenterology , NHS Forth Valley , Stirling, UK
                [12 ] departmentNIHR Nottingham Digestive Diseases Biomedical Research Centre , Queens Medical Centre , Belfast, UK
                [13 ] departmentFaculty of Medicine Health and Life Sciences , Queen’s University Belfast , Belfast, UK
                [14 ] departmentDepartment of Gastroenterology and Hepatology , Radboud University Medical Centre , Nijmegen, The Netherlands
                [15 ] departmentDepartment of Surgery , Durham University , Durham, UK
                Author notes
                [Correspondence to ] Professor Stephen E Attwood, Department of Surgery, Durham University, Durham DH13HP, UK; seaattwood@ 123456gmail.com
                Author information
                http://orcid.org/0000-0003-3109-6933
                Article
                gutjnl-2017-315414
                10.1136/gutjnl-2017-315414
                5969363
                29478034
                87c9b83e-b554-44a4-ac95-16e9a15c581a
                © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

                This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

                History
                : 05 October 2017
                : 03 January 2018
                : 14 January 2018
                Categories
                Guidelines
                1506
                2312
                Custom metadata
                unlocked

                Gastroenterology & Hepatology
                oesophageal strictures,oesophagitis,achalasia,dysphagia
                Gastroenterology & Hepatology
                oesophageal strictures, oesophagitis, achalasia, dysphagia

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