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      The role of ‘artificial intelligence, machine learning, virtual reality, and radiomics’ in PCNL: a review of publication trends over the last 30 years

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          Abstract

          Introduction:

          We wanted to analyze the trend of publications in a period of 30 years from 1994 to 2023, on the application of ‘artificial intelligence (AI), machine learning (ML), virtual reality (VR), and radiomics in percutaneous nephrolithotomy (PCNL)’. We conducted this study by looking at published papers associated with AI and PCNL procedures, including simulation training, with preoperative and intraoperative applications.

          Materials and Methods:

          Although MeSH terms research on the PubMed database, we performed a comprehensive review of the literature from 1994 to 2023 for all published papers on ‘AI, ML, VR, and radiomics’ in ‘PCNL’, with papers in all languages included. Papers were divided into three 10-year periods: Period 1 (1994–2003), Period 2 (2004–2013), and Period 3 (2014–2023).

          Results:

          Over a 30-year timeframe, 143 papers have been published on the subject with 116 (81%) published in the last decade, with a relative increase from Period 2 to Period 3 of +427% ( p = 0.0027). There was a gradual increase in areas such as automated diagnosis of larger stones, automated intraoperative needle targeting, and VR simulators in surgical planning and training. This increase was most marked in Period 3 with automated targeting with 52 papers (45%), followed by the application of AI, ML, and radiomics in predicting operative outcomes (22%, n = 26) and VR for simulation (18%, n = 21). Papers on technological innovations in PCNL ( n = 9), intelligent construction of personalized protocols ( n = 6), and automated diagnosis ( n = 2) accounted for 15% of publications. A rise in automated targeting for PCNL and PCNL training between Period 2 and Period 3 was +247% ( p = 0.0055) and +200% ( p = 0.0161), respectively.

          Conclusion:

          An interest in the application of AI in PCNL procedures has increased in the last 30 years, and a steep rise has been witnessed in the last 10 years. As new technologies are developed, their application in devices for training and automated systems for precise renal puncture and outcome prediction seems to play a leading role in modern-day AI-based publication trends on PCNL.

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          Most cited references32

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            Radiomics: the facts and the challenges of image analysis

            Radiomics is an emerging translational field of research aiming to extract mineable high-dimensional data from clinical images. The radiomic process can be divided into distinct steps with definable inputs and outputs, such as image acquisition and reconstruction, image segmentation, features extraction and qualification, analysis, and model building. Each step needs careful evaluation for the construction of robust and reliable models to be transferred into clinical practice for the purposes of prognosis, non-invasive disease tracking, and evaluation of disease response to treatment. After the definition of texture parameters (shape features; first-, second-, and higher-order features), we briefly discuss the origin of the term radiomics and the methods for selecting the parameters useful for a radiomic approach, including cluster analysis, principal component analysis, random forest, neural network, linear/logistic regression, and other. Reproducibility and clinical value of parameters should be firstly tested with internal cross-validation and then validated on independent external cohorts. This article summarises the major issues regarding this multi-step process, focussing in particular on challenges of the extraction of radiomic features from data sets provided by computed tomography, positron emission tomography, and magnetic resonance imaging.
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              The state of artificial intelligence-based FDA-approved medical devices and algorithms: an online database

              At the beginning of the artificial intelligence (AI)/machine learning (ML) era, the expectations are high, and experts foresee that AI/ML shows potential for diagnosing, managing and treating a wide variety of medical conditions. However, the obstacles for implementation of AI/ML in daily clinical practice are numerous, especially regarding the regulation of these technologies. Therefore, we provide an insight into the currently available AI/ML-based medical devices and algorithms that have been approved by the US Food & Drugs Administration (FDA). We aimed to raise awareness of the importance of regulatory bodies, clearly stating whether a medical device is AI/ML based or not. Cross-checking and validating all approvals, we identified 64 AI/ML based, FDA approved medical devices and algorithms. Out of those, only 29 (45%) mentioned any AI/ML-related expressions in the official FDA announcement. The majority (85.9%) was approved by the FDA with a 510(k) clearance, while 8 (12.5%) received de novo pathway clearance and one (1.6%) premarket approval (PMA) clearance. Most of these technologies, notably 30 (46.9%), 16 (25.0%), and 10 (15.6%) were developed for the fields of Radiology, Cardiology and Internal Medicine/General Practice respectively. We have launched the first comprehensive and open access database of strictly AI/ML-based medical technologies that have been approved by the FDA. The database will be constantly updated.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: MethodologyRole: Writing – original draft
                Role: Formal analysisRole: MethodologyRole: Writing – original draft
                Role: Formal analysisRole: MethodologyRole: Writing – original draft
                Role: InvestigationRole: MethodologyRole: Writing – review & editing
                Role: InvestigationRole: MethodologyRole: Writing – review & editing
                Role: ConceptualizationRole: Writing – review & editing
                Role: ConceptualizationRole: MethodologyRole: Writing – review & editing
                Journal
                Ther Adv Urol
                Ther Adv Urol
                TAU
                sptau
                Therapeutic Advances in Urology
                SAGE Publications (Sage UK: London, England )
                1756-2872
                1756-2880
                8 September 2023
                Jan-Dec 2023
                : 15
                : 17562872231196676
                Affiliations
                [1-17562872231196676]Urology Unit, Azienda Ospedaliero-Universitaria delle Marche, Polytechnic University of Marche, Ancona, Italy
                [2-17562872231196676]Department of Urology, University Hospitals Southampton, NHS Trust, Southampton, UK
                [3-17562872231196676]Department of Urology, University Hospitals Southampton, NHS Trust, Southampton, UK
                [4-17562872231196676]Department of Urology, University Hospitals Southampton, NHS Trust, Southampton, UK
                [5-17562872231196676]Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
                [6-17562872231196676]Urology Unit, Azienda Ospedaliero-Universitaria delle Marche, Polytechnic University of Marche, Ancona, Italy
                [7-17562872231196676]Department of Urology, University Hospitals Southampton, NHS Trust, Southampton, UK
                [8-17562872231196676]Urology Unit, Azienda Ospedaliero-Universitaria delle Marche, Polytechnic University of Marche, Ancona, Italy
                [9-17562872231196676]Professor and Consultant Urological Surgeon, University Hospital Southampton NHS Trust, Tremona Road, Southampton, SO16 6YD, UK
                Author notes
                Author information
                https://orcid.org/0000-0001-7631-3108
                https://orcid.org/0000-0002-6248-6478
                Article
                10.1177_17562872231196676
                10.1177/17562872231196676
                10492475
                37693931
                87c7c3bb-d213-4589-879a-390292f70786
                © The Author(s), 2023

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                : 12 May 2023
                : 3 August 2023
                Categories
                Virtual, Augmented and Mixed Reality in Urology-From Prevention to Follow-up
                Systematic Review
                Custom metadata
                January-December 2023
                ts1

                artificial intelligence,kidney calculi,machine learning,pcnl,radiomics,simulation,urolithiasis

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