Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren.

Methods

Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children.

Results

Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results.

Conclusion

Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value.

Graphical Abstract

Related collections

Most cited references 32

Record: found
Abstract: found
Article: not found

The role of air pollutants in atopic dermatitis.

Kangmo Ahn (2014)

Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease and a growing health concern, especially in children, because of its high prevalence and associated low quality of life. Genetic predisposition, environmental triggers, or interactions between them contribute to the pathophysiology of AD. Therefore, it is very important to identify and control risk factors from the environment in susceptible subjects for successful treatment and prevention. Both indoor and outdoor air pollution, which are of increasing concern with urbanization, are well-known environmental risk factors for asthma, whereas there is relatively little evidence in AD. This review highlights epidemiologic and experimental data on the role of air pollution in patients with AD. Recent evidence suggests that a variety of air pollutants, such as environmental tobacco smoke, volatile organic compounds, formaldehyde, toluene, nitrogen dioxide, and particulate matter, act as risk factors for the development or aggravation of AD. These air pollutants probably induce oxidative stress in the skin, leading to skin barrier dysfunction or immune dysregulation. However, these results are still controversial because of the low number of studies, limitations in study design, inaccurate assessment of exposure and absorption, and many other issues. Further research about the adverse effects of air pollution on AD will help to expand our understanding and to establish a better strategy for the prevention and management of AD.

0 comments Cited 116 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Long-term exposure to close-proximity air pollution and asthma and allergies in urban children.

I Annesi-Maesano, C Kopferschmitt, D Caillaud … (2010)

The aim of this study was to evaluate the impact of urban air pollution, assessed through reliable indicators of exposure, on asthma and allergies in schoolchildren. A validated dispersion model combining data on traffic conditions, topography, meteorology and background pollution was used to relate 3-yrs averaged concentrations of major urban pollutants at the sites of schools to skin prick tests, exercise-induced asthma and reported asthma and allergies in 6,683 children (9-11 yrs) attending 108 schools randomly selected in six French communities. For the 4,907 children who had resided at their current address for the past 3 yrs, asthma (exercise induced, past year and lifetime) was significantly positively associated with benzene, SO(2), particles with a 50% cut-off aerodynamic diameter of 10 microm (PM(10)), nitrogen oxides (NO(x)) and CO. In the same children, eczema (lifetime and past year) was significantly positively associated with benzene, PM(10), NO(2), NO(x) and CO, lifetime allergic rhinitis with PM(10) and sensitisation to pollens with benzene and PM(10). Among the 2,213 children residing at their current address since birth, the associations persisted for lifetime asthma with benzene (adjusted OR per interquartile range (95% CI) 1.3 (1.0-1.9)) and PM(10 )(1.4 (1.0-2.0)), and for sensitisation to pollens with volatile organic compounds (1.3 (1.0-1.9)) and PM(10) (1.2 (1.0-1.9)). Accurately modelled urban air pollution was associated with some measures of childhood asthma and allergies.

0 comments Cited 80 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Symptoms of atopic dermatitis are influenced by outdoor air pollution.

Jihyun Kim, Grace Eun Hye Kim, Inbo Oh … (2013)

0 comments Cited 74 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): J Korean Med Sci

Journal ID (iso-abbrev): J Korean Med Sci

Journal ID (publisher-id): JKMS

Title: Journal of Korean Medical Science

Publisher: The Korean Academy of Medical Sciences

ISSN (Print): 1011-8934

ISSN (Electronic): 1598-6357

Publication date (Electronic): 16 February 2022

Publication date Collection: 28 February 2022

Volume: 37

Issue: 8

Electronic Location Identifier: e63

Affiliations

[1 ]Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.

[2 ]Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.

[3 ]Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

[4 ]Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

[5 ]Department of Data Science, Sejong University College of Software Convergence, Seoul, Korea.

[6 ]Department of Precision Medicine, Sungkyunkwan University School of medicine, Suwon, Korea.

[7 ]Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.

Author notes

Address for Correspondence: Man Yong Han, MD. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea. drmesh@ 123456gmail.com

Author information

Eun Kyo Ha https://orcid.org/0000-0001-8863-5729

Ju Hee Kim https://orcid.org/0000-0002-4945-0753

Dawon Park https://orcid.org/0000-0002-9579-9921

Eun Lee https://orcid.org/0000-0002-0145-7067

Seung Won Lee https://orcid.org/0000-0001-5632-5208

Hye Mi Jee https://orcid.org/0000-0003-0128-065X

Youn Ho Shin https://orcid.org/0000-0003-3227-5511

Man Yong Han https://orcid.org/0000-0002-9077-5779

Article

DOI: 10.3346/jkms.2022.37.e63

PMC ID: 8885456

PubMed ID: 35226421

SO-VID: 87a69f71-f650-4cde-a763-b155444fe2bd

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

History

Date received : 29 September 2021

Date accepted : 17 January 2022

Funding

Funded by: Seongnam Atopy Project for Children Happiness

Award ID: SAP2017

Funded by: National Research Foundation of Korea, CrossRef https://doi.org/10.13039/501100003725;

Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren

Read this article at

Abstract

Background

Methods

Results

Conclusion

Graphical Abstract

Related collections

Karger: Dermatology

Most cited references 32

The role of air pollutants in atopic dermatitis.

Long-term exposure to close-proximity air pollution and asthma and allergies in urban children.

Symptoms of atopic dermatitis are influenced by outdoor air pollution.

Author and article information

Journal

Affiliations

Author notes

Author information

Article

History

Funding

Categories

Comments

Comment on this article

Similar content 468

Cited by 3

Most referenced authors 328