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Abstract
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto"
id="d2891819e77">Among different forms of cyclodextrin (CD), β-CD has been taken a
special attraction
in pharmaceutical science due to lowest aqueous solubility and adequate cavity size.
β-CD forms inclusion complex with drugs in combination with biopolymers such as polysaccharides
which plays a vital role as a vehicle for safe release of drugs. It is noticed that,
β-CD assisted polysaccharide-based composite achieves better drug release rate through
host-guest mechanism. Present review is a critical analysis of this host-guest mechanism
for release of drugs from polysaccharide supported β-CD inclusion complex. Various
important polysaccharides such as cellulose, alginate, chitosan, dextran, etc. and
their association with β-CD in relevant to drug delivery are logically compared in
present review. Efficacy of mechanism of drug delivery by different polysaccharides
with β-CD is analytically examined in schematic form. Drug release capacity at different
pH conditions, mode of drug release, along with characterization techniques adopted
by individual polysaccharide-based CD complexes are comparatively established in tabular
form. This review may explore better visibility for researchers those are working
in the area of controlled release of drugs by carrier consist of β-CD associated polysaccharide
composite through host-guest mechanism.
</p>