Reprogramming of glucose metabolism: Metabolic alterations in the progression of osteosarcoma

Highlights

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  My manuscript discusses the importance of metabolic reprogramming, particularly in glucose metabolism, as an adaptive response of tumor cells under hypoxia and low nutrition conditions. It highlights the increasing evidence that glucose metabolism reprogramming plays a role in regulating the growth and metastasis of osteosarcoma (OS). The manuscript points out that previous research has primarily focused on the glycolytic pathway of glucose metabolism, neglecting the tricarboxylic acid cycle and pentose phosphate pathway, despite their involvement in OS progression. The authors emphasize the need to summarize the research on glucose metabolism in OS. They review the abnormal expression of key molecules related to sugar metabolism and summarize the sugar metabolism-related signaling pathways involved in the occurrence and development of OS. Additionally, the manuscript discusses targeted drugs that regulate sugar metabolism pathways and their potential for effective targeted treatment of OS.

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  My manuscript addresses an important topic in cancer research, specifically the role of metabolic reprogramming and glucose metabolism in osteosarcoma. The authors highlight the existing gap in understanding the involvement of the tricarboxylic acid cycle and pentose phosphate pathway in OS, which suggests the need for further investigation in this area. The review of abnormal expression of key molecules and signaling pathways related to sugar metabolism provides valuable insights into the molecular mechanisms underlying OS development. The discussion on targeted drugs that regulate sugar metabolism pathways also opens up possibilities for potential therapeutic strategies. Overall, this manuscript contributes to the field by summarizing and emphasizing the significance of glucose metabolism pathways in osteosarcoma, providing a foundation for future research and potential advancements in diagnosis and treatment.

Abstract

Metabolic reprogramming is an adaptive response of tumour cells under hypoxia and low nutrition conditions. There is increasing evidence that glucose metabolism reprogramming can regulate the growth and metastasis of osteosarcoma (OS). Reprogramming in the progress of OS can bring opportunities for early diagnosis and treatment of OS. Previous research mainly focused on the glycolytic pathway of glucose metabolism, often neglecting the tricarboxylic acid cycle and pentose phosphate pathway. However, the tricarboxylic acid cycle and pentose phosphate pathway of glucose metabolism are also involved in the progression of OS and are closely related to this disease. The research on glucose metabolism in OS has not yet been summarized. In this review, we discuss the abnormal expression of key molecules related to glucose metabolism in OS and summarize the glucose metabolism related signaling pathways involved in the occurrence and development of OS. In addition, we discuss some of the targeted drugs that regulate glucose metabolism pathways, which can lead to effective strategies for targeted treatment of OS.