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Molecular targets of vitexin and isovitexin in cancer therapy: a critical review : Anticancer mechanisms of vitexin and isovitexin
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Abstract
<p class="first" id="d17893411e59">Cancer is a primary public health problem and the
second leading cause of death worldwide.
It causes life-threatening malignancies and results in high financial costs for both
patients and the healthcare system. Hence, it is important to develop effective long-term
strategies pertaining to prevention and control of cancers. Plant-derived secondary
metabolites have been shown to have positive roles against various cancers. A number
of plant extracts have been evaluated for possible use in the treatment of cancer;
some have provided direction for new strategies for the research and development of
antitumor agents. Here, we provide comprehensive data on various cancers, potential
molecular mechanisms, and therapeutic implications of just two plant-derived compounds,
vitexin and isovitexin. Information on the chemotherapeutic potential of vitexin and
isovitexin was collected from a library database and through electronic searches (ScienceDirect,
Pubmed, and Google Scholar). Both in vitro and in vivo studies suggest that vitexin
and isovitexin are chemopreventive compounds with activity against various cancers
through proapoptotic processes and/or autophagy.
</p>