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Actinomycin and DNA transcription.

Publication date: 1985-07-31

Journal: Proceedings of the National Academy of Sciences of the United States of America

Keywords: Animals, Cell Nucleolus, metabolism, DNA-Directed RNA Polymerases, Dactinomycin, pharmacology, Microscopy, Electron, Models, Molecular, Molecular Conformation, Nucleic Acid Conformation, Nucleic Acid Denaturation, Transcription, Genetic, drug effects

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Abstract

Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.

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PubMed ID:: 2410919

PMC ID:: 390561

DOI:: 10.1073/pnas.82.16.5328

ScienceOpen disciplines: Chemistry

Keywords: Animals,Cell Nucleolus,metabolism,DNA-Directed RNA Polymerases,Dactinomycin,pharmacology,Microscopy, Electron,Models, Molecular,Molecular Conformation,Nucleic Acid Conformation,Nucleic Acid Denaturation,Transcription, Genetic,drug effects

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ScienceOpen disciplines: Chemistry

Actinomycin and DNA transcription.

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