Ketoconazole in Cushing&apos;s disease: is it worth a try?

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The use of ketoconazole has been recently questioned after warnings from the European Medicine Agencies and the Food and Drug Administration due to potential hepatotoxicity. However, ketoconazole is frequently used as a drug to lower circulating cortisol levels. Several pharmacological agents have recently been approved for the treatment of Cushing's disease (CD) despite limited efficacy or significant side effects. Ketoconazole has been used worldwide for more than 30 years in CD, but in the absence of a large-scale study, its efficacy and tolerance are still under debate.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): J Clin Endocrinol Metab

Title: The Journal of clinical endocrinology and metabolism

Publisher: The Endocrine Society

ISSN (Electronic): 1945-7197

ISSN (Print): 0021-972X

Publication date (Electronic): May 2014

Volume: 99

Issue: 5

Affiliations

[1 ] Aix Marseille Université, Hopital de la Timone (F.C., M.P., I.M., B.C.-D., T.B.), Service d'Endocrinologie, 13005, Marseille, France; Hôpital Cochin Service d'Endocrinologie et Maladies Métaboliques (L.G., L.Q., C.B., J.B.), 75014, Paris, France; Centre Hospitalier Universitaire (CHU) de Bordeaux Hôpital du Haut Lévêque Service d'Endocrinologie-Diabétologie et Maladies Métaboliques (P.G., A.T.), 33600 Pessac, France; CHU de Grenoble Hôpital Albert Michallon Service d'Endocrinologie-Diabétologie-Nutrition (M.Mu., M.Ma., O.C.), 38043, Grenoble, France; Université Paris-Sud Service d'Endocrinologie et Maladies de la Reproduction (P.K., P.Ch., J.Y.), 94270, Le Kremlin Bicetre, France; CHU de Nantes Hôpital G & R Laënnec St-Herblain Endocrinologie, Maladies Métaboliques et Nutrition (D.D., M.L.B.), 44093, Nantes, France; Hôpital Larrey Service d'Endocrinologie-Maladies Métaboliques-Nutrition (P.Ca., D.V.), 31400, Toulouse, France; CHU de Strasbourg Hôpital de Hautepierre (F.L., B.G.), Service de Médecine Interne et de Nutrition, 67100 Strasbourg, France; Assistance Publique-Hôpitaux de Paris, Hôpital St-Antoine Service d'Endocrinologie-Diabétologie et Médecine de la Reproduction (B.Do., S.C.-M.), 75012, Paris, France; Centre Hospitalier Regional Universitaire de Lille Hôpital Claude Huriez, Service d'Endocrinologie Métabolisme (M.C.V.), 59000 Lille, France; Hôpital Avicenne Service d'Endocrinologie, Diabétologie, et Maladies Métaboliques (H.B.), 93000 Bobigny, France; CHU de Reims Hôpital Robert Debré (B.De.), Service d'Endocrinologie-Diabète-Nutrition, 51092, Reims, France; Hôpital Neuro-cardiologique Fédération d'Endocrinologie du Pôle Est (G.R.), 39500 Bron, France; and Hôpital de Bicêtre Endocrinologie Pédiatrique (E.M.), 94270, Le Kremlin Bicetre, France.

Article

DOI: 10.1210/jc.2013-3628

PubMed ID: 24471573

SO-VID: 8507f039-99f4-4a61-9a63-0382f11b7d35

History

Data availability:

Comments

Comment on this article

scite_

266

239

Smart Citations

266

239

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.