- Record: found
- Abstract: found
- Article: not found
Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.
Matthew G Krebs
1 ,
Jian-Mei Hou ,
Robert Sloane ,
Lee Lancashire ,
Lynsey Priest ,
Daisuke Nonaka ,
Tim H Ward ,
Alison Backen ,
Glen Clack ,
Andrew Hughes ,
Malcolm Ranson ,
Fiona H Blackhall ,
Caroline Dive
Feb 2012
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Epithelial circulating tumor cells (CTCs) are detectable in patients with non-small cell lung cancer (NSCLC). However, epithelial to mesenchymal transition, a widely reported prerequisite for metastasis, may lead to an underestimation of CTC number. We compared directly an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs. Molecular characteristics of CTCs were also explored.