Topologic Analysis of Plasma Mitochondrial DNA Reveals the Coexistence of Both Linear and Circular Molecules.

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Abstract

Cellular mitochondrial DNA (mtDNA) is organized as circular, covalently closed and double-stranded DNA. Studies have demonstrated the presence of short mtDNA fragments in plasma. It is not known whether circular mtDNA might concurrently exist with linear mtDNA in plasma.

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Journal

Journal ID (iso-abbrev): Clin. Chem.

Title: Clinical chemistry

Publisher: American Association for Clinical Chemistry (AACC)

ISSN (Electronic): 1530-8561

ISSN (Print): 0009-9147

Publication date (Electronic): Sep 2019

Volume: 65

Issue: 9

Affiliations

[1 ] Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

[2 ] Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

[3 ] Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

[4 ] Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

[5 ] Sir Y.K. Pao Centre for Cancer and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

[6 ] Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

[7 ] State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

[8 ] Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; loym@cuhk.edu.hk.

Article

Publisher Item ID: clinchem.2019.308122

DOI: 10.1373/clinchem.2019.308122

PubMed ID: 31263037

SO-VID: 8308a440-c1e0-40f0-ad94-187ff8abd072

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