Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis.

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Abstract

Many genomic loci have been identified for multiple sclerosis (MS) by genome-wide association studies (GWAS). Discrimination of the most functionally relevant genes in these loci remains challenging. The aim of this study was to highlight potential causal genes for MS.

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Journal

Journal ID (iso-abbrev): J. Neurol.

Title: Journal of neurology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1432-1459

ISSN (Print): 0340-5354

Publication date (Electronic): Nov 2019

Volume: 266

Issue: 11

Affiliations

[1 ] Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, People's Republic of China.

[2 ] Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, People's Republic of China.

[3 ] Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Department of Epidemiology, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, People's Republic of China.

[4 ] Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, People's Republic of China.

[5 ] Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, People's Republic of China. hzhang3@suda.edu.cn.

[6 ] Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Department of Epidemiology, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, People's Republic of China. hzhang3@suda.edu.cn.

Article

Publisher Item ID: 10.1007/s00415-019-09476-w

DOI: 10.1007/s00415-019-09476-w

PubMed ID: 31321514

SO-VID: 82dace79-40cb-4ca1-ba14-58dee15d9fb0

History

Keywords: Multiple sclerosis,Genome-wide association study,Mendelian randomization,Methylation

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Keywords: Multiple sclerosis, Genome-wide association study, Mendelian randomization, Methylation

Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis.

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Karger: Neurology and Neuroscience

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