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The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis
Hiroki Kobayashi ,
Krystyna A. Gieniec ,
Tamsin R.M. Lannagan ,
Tongtong Wang ,
Naoya Asai ,
Yasuyuki Mizutani ,
Tadashi Iida ,
Ryota Ando ,
Elaine M. Thomas ,
Akihiro Sakai ,
Nobumi Suzuki ,
Mari Ichinose ,
Josephine A. Wright ,
Laura Vrbanac ,
Jia Q. Ng ,
Jarrad Goyne ,
Georgette Radford ,
Matthew J. Lawrence ,
Tarik Sammour ,
Yoku Hayakawa ,
Sonja Klebe ,
Alice E. Shin ,
Samuel Asfaha ,
Mark L. Bettington ,
Florian Rieder ,
Nicholas Arpaia ,
Tal Danino ,
Lisa M. Butler ,
Alastair D. Burt ,
Simon J. Leedham ,
Anil K. Rustgi ,
Siddhartha Mukherjee ,
Masahide Takahashi ,
Timothy C. Wang ,
Atsushi Enomoto ,
Susan L. Woods ,
Daniel L. Worthley
December 2021
December 2021
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Abstract
Cancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC)
progression and predict poor prognosis in CRC patients. However, the cellular origins
of CAFs remain unknown, making it challenging to therapeutically target these cells.
Here, we aimed to identify the origins and contribution of colorectal CAFs associated
with poor prognosis.