Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells.

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Abstract

UDP-glucuronosyltransferase (UGT) enzymes catalyze the glucuronidation and typically inactivation of endogenous and exogenous molecules including steroid hormones, bilirubin and many drugs. The UGT1A6 protein is expressed predominantly in liver and metabolizes small phenolic drugs including acetaminophen, salicylates and many beta-blockers. Interindividual variation in the capacity of humans to glucuronidate drugs has been observed.

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Journal

Journal ID (iso-abbrev): Pharmacogenetics

Title: Pharmacogenetics

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN: 0960-314X

ISSN (Print): 0960-314X

Publication date (Electronic): Aug 2004

Volume: 14

Issue: 8

Affiliations

[1 ] Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Article

Publisher Item ID: 00008571-200408000-00002

DOI: 10.1097/01.fpc.0000114771.78957.cb

PubMed ID: 15284531

SO-VID: 80db5c97-3be4-4598-8157-7da9997b0685

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