Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial.

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Abstract

Previous studies of patients with chronic lymphocytic leukaemia reported high response rates to fludarabine combined with cyclophosphamide. We aimed to establish whether this treatment combination provided greater survival benefit than did chlorambucil or fludarabine.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Jul 21 2007

Volume: 370

Issue: 9583

Affiliations

[1 ] Section of Haemato-Oncology, Institute of Cancer Research, Sutton, UK. Electronic address: daniel.catovsky@icr.ac.uk.

[2 ] Clinical Trial Service Unit, Oxford, UK.

[3 ] Section of Haemato-Oncology, Institute of Cancer Research, Sutton, UK.

[4 ] Royal Bournemouth Hospital, Bournemouth, UK.

[5 ] Leicester Royal Infirmary, Leicester, UK.

[6 ] Hospital Alvarez, Buenos Aires, Argentina.

[7 ] University of Liverpool, Liverpool, UK.

[8 ] Heartlands Hospital, Birmingham, UK.

[9 ] Leeds General Infirmary, Leeds, UK.

[10 ] Good Hope Hospital, Sutton Coldfield, UK.

[11 ] Southampton General Hospital, Southampton, UK.

[12 ] Bath Cancer Research, Bath, UK.

Article

Publisher Item ID: S0140-6736(07)61125-8

DOI: 10.1016/S0140-6736(07)61125-8

PubMed ID: 17658394

SO-VID: 803b20df-4b1d-4c22-ba1e-d62cecfd8e42

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