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      Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells

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          Abstract

          We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane ( 1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, cirsiliol ( 11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin ( 12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7). These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.

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          The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.

          Hyunjung Lee, Suna Kim, Jiyun Ahn … (2008)
          Quercetin is the most abundant flavonoid and is assumed to have protective roles against the pathogenesis of multiple diseases associated with oxidative stress. In the present study, we investigated the molecular mechanisms by which quercetin affects adipogenesis and apoptosis in 3T3-L1 cells. The exposure of 3T3-L1 preadipocytes to quercetin resulted in attenuated adipogenesis and decreased expression of adipogenesis-related factors and enzymes. Moreover, quercetin exposure up-regulated the levels of phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and its substrate, acetyl-CoA carboxylase (ACC). Treatment of 3T3-L1 adipocytes with quercetin resulted in the induction of apoptosis and a concomitant decrease in ERK and JNK phosphorylation. Taken together, these data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercetin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.
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            Enzymes of glycerolipid synthesis in eukaryotes.

            Denis Coleman, R Bell (1979)
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              Obesity: epidemiology and clinical aspects.

              X Formiguera, Ana Canton (2004)
              At the beginning of the 21st Century, obesity has become the leading metabolic disease in the World. So much so, that the World Health Organisation refers to obesity as the global epidemic. In fact, obesity is a common disease affecting not only affluent societies but also developing countries. Currently 300 million people can be considered as obese and, due to the rising trend in obesity prevalence, this figure could double by year 2025 if no action is taken against this threat. In terms of health impairment, the importance of obesity lies in the fact that, besides being a disease in itself, it is a risk for many other diseases, mainly from the metabolic and cardiovascular area. Among these, type 2 diabetes, dyslipemia, hyperuricemia, arterial hypertension and cardiovascular disease are the most frequent. Also, respiratory diseases such as obesity hypoventilation syndrome and obstructive sleep apnoea syndrome are strongly associated with obesity.
              Article 0 comments Cited 39 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Susumu Kitanaka: +81-47-4655356 , +81-47-4655440 , kitanaka.susumu@nihon-u.ac.jp
                Journal
                Journal ID (nlm-ta): J Nat Med
                Journal ID (iso-abbrev): J Nat Med
                Title: Journal of Natural Medicines
                Publisher: Springer Japan (Tokyo )
                ISSN (Print): 1340-3443
                ISSN (Electronic): 1861-0293
                Publication date (Electronic): 20 October 2013
                Publication date PMC-release: 20 October 2013
                Publication date (Print): 2014
                Volume: 68
                Pages: 414-420
                Affiliations
                School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555 Japan
                Article
                Publisher ID: 799
                DOI: 10.1007/s11418-013-0799-3
                PMC ID: 3948510
                PubMed ID: 24142543
                SO-VID: 7fcde978-9a13-4ba7-930d-6f1fe61bf482
                Copyright © © The Author(s) 2013
                License:

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

                History
                Date received : 24 June 2013
                Date accepted : 8 August 2013
                Categories
                Subject: Note
                Custom metadata
                issue-copyright-statement © The Japanese Society of Pharmacognosy and Springer Japan 2014

                ScienceOpen disciplines: Complementary & Alternative medicine
                Keywords: artemisia scoparia waldst. et kit.,chromane,triglyceride,nitric oxide
                Data availability:
                ScienceOpen disciplines: Complementary & Alternative medicine
                Keywords: artemisia scoparia waldst. et kit., chromane, triglyceride, nitric oxide

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