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      • Record: found
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      Rare Occurrence of Acute Hematogenous Periprosthetic Joint Infection Due to Fusobacterium Nucleatum in the Background of a Dental Procedure: A Case Report

      case-report

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          Abstract

          Objective

          Fusobacterium nucleatum is an anaerobic gram‐negative bacilli that is one of the oral and other mucosal surface microbiota. It involves a wide range of human diseases and was first found in periodontal diseases, but reports of bone‐related infections caused by F. nucleatum are rare, especially periprosthetic joint infections (PJI).

          Methods

          Here, we present the first case of acute hematogenous PJI of the hip joint caused by F. nucleatum, and debridement, antibiotics, and implant retention (DAIR) was performed.

          Results

          The patient was successfully treated with DAIR, identification of isolates by metagenomics next‐generation sequencing was confirmed by polymerase chain reaction.

          Conclusions

          For stable acute hematogenous PJI after hip replacement, quick and accurate diagnosis, the identification of pathogenic microorganisms, and the use of DAIR combined with sufficient sensitive antibiotics have a certain clinical effect and can achieve the purpose of both preserving the prosthesis and infection control.

          Abstract

          Successful treatment of F. nucleatum PJI with DAIR (debridement, antibiotics, implant retention).

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          Most cited references17

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          Sonication of removed hip and knee prostheses for diagnosis of infection.

          Andrej Trampuz, Kerryl E. Piper, Melissa Jacobson … (2007)
          Culturing of samples of periprosthetic tissue is the standard method used for the microbiologic diagnosis of prosthetic-joint infection, but this method is neither sensitive nor specific. In prosthetic-joint infection, microorganisms are typically present in a biofilm on the surface of the prosthesis. We hypothesized that culturing of samples obtained from the prosthesis would improve the microbiologic diagnosis of prosthetic-joint infection. We performed a prospective trial comparing culture of samples obtained by sonication of explanted hip and knee prostheses to dislodge adherent bacteria from the prosthesis with conventional culture of periprosthetic tissue for the microbiologic diagnosis of prosthetic-joint infection among patients undergoing hip or knee revision or resection arthroplasty. We studied 331 patients with total knee prostheses (207 patients) or hip prostheses (124 patients); 252 patients had aseptic failure, and 79 had prosthetic-joint infection. With the use of standardized nonmicrobiologic criteria to define prosthetic-joint infection, the sensitivities of periprosthetic-tissue and sonicate-fluid cultures were 60.8% and 78.5% (P<0.001), respectively, and the specificities were 99.2% and 98.8%, respectively. Fourteen cases of prosthetic-joint infection were detected by sonicate-fluid culture but not by prosthetic-tissue culture. In patients receiving antimicrobial therapy within 14 days before surgery, the sensitivities of periprosthetic tissue and sonicate-fluid culture were 45.0% and 75.0% (P<0.001), respectively. In this study, culture of samples obtained by sonication of prostheses was more sensitive than conventional periprosthetic-tissue culture for the microbiologic diagnosis of prosthetic hip and knee infection, especially in patients who had received antimicrobial therapy within 14 days before surgery. Copyright 2007 Massachusetts Medical Society.
          Article 0 comments Cited 310 times – based on 0 reviews     Review now
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            Fusobacterium nucleatum: a commensal-turned pathogen.

            Yiping W. Han (2015)
            Fusobacterium nucleatum is an anaerobic oral commensal and a periodontal pathogen associated with a wide spectrum of human diseases. This article reviews its implication in adverse pregnancy outcomes (chorioamnionitis, preterm birth, stillbirth, neonatal sepsis, preeclampsia), GI disorders (colorectal cancer, inflammatory bowel disease, appendicitis), cardiovascular disease, rheumatoid arthritis, respiratory tract infections, Lemierre's syndrome and Alzheimer's disease. The virulence mechanisms involved in the diseases are discussed, with emphasis on its colonization, systemic dissemination, and induction of host inflammatory and tumorigenic responses. The FadA adhesin/invasin conserved in F. nucleatum is a key virulence factor and a potential diagnostic marker for F. nucleatum-associated diseases.
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              Fusobacterium nucleatum in periodontal health and disease.

              Pierre Poulet, Christine Roques, Benoit Signat … (2010)
              The pathogenesis of periodontitis involves the interplay of microbiota present in the subgingival plaque and the host responses. Inflammation and destruction of periodontal tissues are considered to result from the response of a susceptible host to a microbial biofilm containing gram-negative pathogens. Antimicrobial peptides are important contributors to maintaining the balance between health and disease in this complex environment. These include several salivary antimicrobial peptides such as β-defensins expressed in the epithelium and LL-37 expressed in both epithelium and neutrophils. Among gram-negative bacteria implicated in periodontal diseases, Fusobacterium nucleatum, is one of the most interesting. This review will focus on expression, function, regulation and functional efficacy of antimicrobial peptides against F. nucleatum. We are looking for how the presence of F. nucleatum induces secretion of peptides which have an impact on host cells and modulate immune response.
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                Author and article information

                Contributors
                Teng‐bin Shi:
                ORCID: https://orcid.org/0000-0001-8065-7413
                shitengbin52012@163.com
                Wen‐ming Zhang:
                ORCID: https://orcid.org/0000-0003-1567-7279
                zhangwm0591@fjmu.edu.cn
                Journal
                Journal ID (nlm-ta): Orthop Surg
                Journal ID (iso-abbrev): Orthop Surg
                Journal ID (doi): 10.1111/(ISSN)1757-7861
                Journal ID (publisher-id): OS
                Title: Orthopaedic Surgery
                Publisher: John Wiley & Sons Australia, Ltd (Melbourne )
                ISSN (Print): 1757-7853
                ISSN (Electronic): 1757-7861
                Publication date (Electronic): 04 November 2020
                Publication date Collection: December 2020
                Volume: 12
                Issue: 6 ( doiID: 10.1111/os.v12.6 )
                Pages: 2026-2030
                Affiliations
                [ 1 ] Department of Orthopaedic Surgery First Affiliated Hospital of Fujian Medical University Fuzhou China
                Author notes
                [*] [* ] Address for correspondence Wen‐ming Zhang, MD, PhD, Department of Orthopaedics, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, China 350005 Tel: 001‐591‐87982113; Email: zhangwm0591@ 123456fjmu.edu.cn
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0001-8065-7413
                https://orcid.org/0000-0001-6337-8009
                https://orcid.org/0000-0003-2624-1315
                https://orcid.org/0000-0001-7397-2298
                https://orcid.org/0000-0001-6131-8766
                https://orcid.org/0000-0003-1567-7279
                Article
                Publisher ID: OS12844
                DOI: 10.1111/os.12844
                PMC ID: 7767770
                PubMed ID: 33150710
                SO-VID: 7f03181d-5d83-436a-84bd-e7a24d82cd13
                Copyright © © 2020 The Authors. Orthopaedic Surgery published by Chinese Orthopaedic Association and John Wiley & Sons Australia, Ltd.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 02 July 2020
                Date revision received : 17 August 2020
                Date accepted : 23 August 2020
                Page count
                Figures: 4, Tables: 0, Pages: 5, Words: 3068
                Categories
                Subject: Case Report
                Subject: Case Reports
                Custom metadata
                source-schema-version-number 2.0
                cover-date December 2020
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.6 mode:remove_FC converted:27.12.2020

                Keywords: debridement, antibiotics, and implant retention (dair),fusobacterium nucleatum,periprosthetic joint infections
                Data availability:
                Keywords: debridement, antibiotics, and implant retention (dair), fusobacterium nucleatum, periprosthetic joint infections

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