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      Public awareness regarding the manufacturer provided information about medicine usage, safety, and adverse drug reactions in Balochistan, Pakistan

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          Abstract

          Objectives: This study aimed to analyze the general public’s awareness of medicine information, safety, and adverse drug reactions in Quetta, Pakistan.

          Methods: A cross-sectional descriptive study was conducted using random sampling from April 2020 to April 2021 in Quetta. Samples were collected from respondents who met the inclusion criteria and had visited community pharmacies. The analysis was done using SPSS version 23. Bivariate and multivariate analyses were performed to assess factors associated with good knowledge.

          Results: Multivariate analysis revealed that purchase on prescription was a determining factor of knowledge regarding knowledge of pharmaceutical products and their provided information, medicines usage and safety, and Medication ADRs. Patients who bought medicines on prescriptions were more likely to have better knowledge. Patients having education were more likely to have better knowledge.

          Conclusion: Public awareness about medicine information, safety, and the information provided by manufacturers is crucial to ensuring that patients have access to accurate information about their medications and can make informed decisions about their health. Healthcare providers and regulatory bodies must work together to improve access to information and promote safe medication practices.

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          Most cited references36

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          Low health literacy and health outcomes: an updated systematic review.

          Approximately 80 million Americans have limited health literacy, which puts them at greater risk for poorer access to care and poorer health outcomes. To update a 2004 systematic review and determine whether low health literacy is related to poorer use of health care, outcomes, costs, and disparities in health outcomes among persons of all ages. English-language articles identified through MEDLINE, CINAHL, PsycINFO, ERIC, and Cochrane Library databases and hand-searching (search dates for articles on health literacy, 2003 to 22 February 2011; for articles on numeracy, 1966 to 22 February 2011). Two reviewers independently selected studies that compared outcomes by differences in directly measured health literacy or numeracy levels. One reviewer abstracted article information into evidence tables; a second reviewer checked information for accuracy. Two reviewers independently rated study quality by using predefined criteria, and the investigative team jointly graded the overall strength of evidence. 96 relevant good- or fair-quality studies in 111 articles were identified: 98 articles on health literacy, 22 on numeracy, and 9 on both. Low health literacy was consistently associated with more hospitalizations; greater use of emergency care; lower receipt of mammography screening and influenza vaccine; poorer ability to demonstrate taking medications appropriately; poorer ability to interpret labels and health messages; and, among elderly persons, poorer overall health status and higher mortality rates. Poor health literacy partially explains racial disparities in some outcomes. Reviewers could not reach firm conclusions about the relationship between numeracy and health outcomes because of few studies or inconsistent results among studies. Searches were limited to articles published in English. No Medical Subject Heading terms exist for identifying relevant studies. No evidence concerning oral health literacy (speaking and listening skills) and outcomes was found. Low health literacy is associated with poorer health outcomes and poorer use of health care services. Agency for Healthcare Research and Quality.
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            A QUANTITATIVE APPROACH TO CONTENT VALIDITY

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              Literacy and misunderstanding prescription drug labels.

              Health literacy has increasingly been viewed as a patient safety issue and may contribute to medication errors. To examine patients' abilities to understand and demonstrate instructions found on container labels of common prescription medications. Cross-sectional study using in-person, structured interviews. 3 primary care clinics serving mostly indigent populations in Shreveport, Louisiana; Jackson, Michigan; and Chicago, Illinois. 395 English-speaking adults waiting to see their providers. Correct understanding of instructions on 5 container labels; demonstration of 1 label's dosage instructions. Correct understanding of the 5 labels ranged from 67.1% to 91.1%. Patients reading at or below the sixth-grade level (low literacy) were less able to understand all 5 label instructions. Although 70.7% of patients with low literacy correctly stated the instructions, "Take two tablets by mouth twice daily," only 34.7% could demonstrate the number of pills to be taken daily. After potential confounding variables were controlled for, low (adjusted relative risk, 2.32 [95% CI, 1.26 to 4.28]) and marginal (adjusted relative risk, 1.94 [CI, 1.14 to 3.27]) literacy were significantly associated with misunderstanding. Taking a greater number of prescription medications was also statistically significantly associated with misunderstanding (adjusted relative risk, 2.98 [CI, 1.40 to 6.34] for > or =5 medications). The study sample was at high risk for poor health literacy and outcomes. Most participants were women, and all spoke English. The authors did not examine the association between misunderstanding and medication error or evaluate patients' actual prescription drug-taking behaviors. Lower literacy and a greater number of prescription medications were independently associated with misunderstanding the instructions on prescription medication labels.
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                Author and article information

                Contributors
                Journal
                Front Pharmacol
                Front Pharmacol
                Front. Pharmacol.
                Frontiers in Pharmacology
                Frontiers Media S.A.
                1663-9812
                20 July 2023
                2023
                : 14
                : 1190741
                Affiliations
                [1] 1 Faculty of Pharmacy and Health Sciences , University of Balochistan , Quetta, Pakistan
                [2] 2 Provincial Drug Testing Laboratory Balochistan , Quetta, Pakistan
                [3] 3 Sardar Begum Dental Hospital , Peshawar, Pakistan
                [4] 4 Balochistan Institute of Nephrology Urology Quetta , Quetta, Pakistan
                [5] 5 Sardar Bahadur Khan Women’s University , Quetta, Pakistan
                [6] 6 Capital University of Science & Technology , Islamabad, Pakistan
                [7] 7 Department of Pharmacy , University of Punjab , Lahore, Pakistan
                [8] 8 Civil Hospital Quetta , Quetta, Pakistan
                Author notes

                Edited by: Marcus Tolentino Silva, University of Sorocaba, Brazil

                Reviewed by: Muhammad Usman, University of Veterinary and Animal Sciences, Pakistan

                Patrick Maison, Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM), France

                *Correspondence: Gullab Khan, gullabkhankakar@ 123456gmail.com
                Article
                1190741
                10.3389/fphar.2023.1190741
                10399575
                37547330
                7dda5873-53a9-40f7-ab98-04466251d65b
                Copyright © 2023 Khan, Haq, Ahmad, Nasim, Javaid, Saood, Yasmin, Tahir, Riaz, Danish, Razzaq, Khan, Younis and Rabbani.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 21 March 2023
                : 16 May 2023
                Categories
                Pharmacology
                Original Research
                Custom metadata
                Drugs Outcomes Research and Policies

                Pharmacology & Pharmaceutical medicine
                public awareness,medicine information,safety,quetta,pakistan

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