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Recycling of SLC38A1 to the plasma membrane by DSCR3 promotes acquired temozolomide resistance in glioblastoma
Rui Lin ,
Yimin Xu ,
Sidi Xie ,
Yunxiao Zhang ,
Hai Wang ,
Guo-Zhong Yi ,
Guanglong Huang ,
Bowen Ni ,
Haimin Song ,
Ziyu Wang ,
Song-Tao Qi ,
Yawei Liu
February 21 2022
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Abstract
Glioblastoma multiforme (GBM) is a primary brain tumor with devastating prognosis.
Although the O6-methylguanine-DNA methyltransferase (MGMT) leads to inherent temozolomide
(TMZ) resistance, approximately half of GBMs were sufficient to confer acquired TMZ
resistance, which express low levels of MGMT. The purpose of this study was to investigate
the underlying mechanisms of the acquired TMZ resistance in MGMT-deficient GBM.