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      Amide proton transfer magnetic resonance imaging to evaluate renal impairment in patients with chronic kidney disease

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          Abstract

          We aimed to investigate the value of amide proton transfer magnetic resonance imaging (APT-MRI) in the classification of chronic kidney disease (CKD).

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          Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI.

          Jinyuan Zhou, Jean-Francois Payen, David A H Wilson … (2003)
          In the past decade, it has become possible to use the nuclear (proton, 1H) signal of the hydrogen atoms in water for noninvasive assessment of functional and physiological parameters with magnetic resonance imaging (MRI). Here we show that it is possible to produce pH-sensitive MRI contrast by exploiting the exchange between the hydrogen atoms of water and the amide hydrogen atoms of endogenous mobile cellular proteins and peptides. Although amide proton concentrations are in the millimolar range, we achieved a detection sensitivity of several percent on the water signal (molar concentration). The pH dependence of the signal was calibrated in situ, using phosphorus spectroscopy to determine pH, and proton exchange spectroscopy to measure the amide proton transfer rate. To show the potential of amide proton transfer (APT) contrast for detecting acute stroke, pH effects were noninvasively imaged in ischemic rat brain. This observation opens the possibility of using intrinsic pH contrast, as well as protein- and/or peptide-content contrast, as diagnostic tools in clinical imaging.
          Article 0 comments Cited 267 times – based on 0 reviews     Review now
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            Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

            Adeera Levin, Marcello Tonelli, Joseph Bonventre … (2017)
            The global nephrology community recognises the need for a cohesive plan to address the problem of chronic kidney disease (CKD). In July, 2016, the International Society of Nephrology hosted a CKD summit of more than 85 people with diverse expertise and professional backgrounds from around the globe. The purpose was to identify and prioritise key activities for the next 5-10 years in the domains of clinical care, research, and advocacy and to create an action plan and performance framework based on ten themes: strengthen CKD surveillance; tackle major risk factors for CKD; reduce acute kidney injury-a special risk factor for CKD; enhance understanding of the genetic causes of CKD; establish better diagnostic methods in CKD; improve understanding of the natural course of CKD; assess and implement established treatment options in patients with CKD; improve management of symptoms and complications of CKD; develop novel therapeutic interventions to slow CKD progression and reduce CKD complications; and increase the quantity and quality of clinical trials in CKD. Each group produced a prioritised list of goals, activities, and a set of key deliverable objectives for each of the themes. The intended users of this action plan are clinicians, patients, scientists, industry partners, governments, and advocacy organisations. Implementation of this integrated comprehensive plan will benefit people who are at risk for or affected by CKD worldwide.
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              APT-weighted MRI: Techniques, current neuro applications, and challenging issues

              Jinyuan Zhou, Hye-Young Heo, Linda Knutsson … (2019)
              Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer (CEST) imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this paper, we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we will outline technical challenges for clinical APT-based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo.
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                Author and article information

                Journal
                Title: Magnetic Resonance Imaging
                Abbreviated Title: Magnetic Resonance Imaging
                Publisher: Elsevier BV
                ISSN (Print): 0730725X
                Publication date Created: April 2022
                Publication date (Print): April 2022
                Volume: 87
                Pages: 177-182
                Article
                DOI: 10.1016/j.mri.2021.11.015
                PubMed ID: 34863880
                SO-VID: 7dbf52a5-f6e0-4224-8627-6a187bc695b9
                Copyright © © 2022
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                https://www.elsevier.com/tdm/userlicense/1.0/

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