Hemodynamic disturbed flow induces differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo.

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Abstract

Hemodynamic disturbed flow (DF) is associated with susceptibility to atherosclerosis. Endothelial Kruppel-Like Factor 4 (KLF4) is an important anti-inflammatory atheroprotective transcription factor that is suppressed in regions of DF.

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Author and article information

Journal

Journal ID (iso-abbrev): Circ Res

Title: Circulation research

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4571

ISSN (Print): 0009-7330

Publication date (Electronic): Jun 20 2014

Volume: 115

Issue: 1

Affiliations

[1 ] From the Department of Pathology & Laboratory Medicine and Institute for Medicine & Engineering (Y.-Z.J., J.M.J., M.E.M., L.-D.Z., P.F.D.) and Pharmacology Graduate Group (K.O.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

[2 ] From the Department of Pathology & Laboratory Medicine and Institute for Medicine & Engineering (Y.-Z.J., J.M.J., M.E.M., L.-D.Z., P.F.D.) and Pharmacology Graduate Group (K.O.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. pfd@mail.med.upenn.edu.

Article

Publisher Item ID: CIRCRESAHA.115.303883 Mid ID: NIHMS589663

DOI: 10.1161/CIRCRESAHA.115.303883

PMC ID: 4065854

PubMed ID: 24755985

SO-VID: 7d826c18-a8e8-47cd-abfb-67ebc3d3dd4a

History

Keywords: DNA methylation,atherosclerosis,epigenetics,hemodynamics

Data availability:

Keywords: DNA methylation, atherosclerosis, epigenetics, hemodynamics

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