Improved Bioprocess with CHO-hTSH Cells on Higher Microcarrier Concentration Provides Higher Overall Biomass and Productivity for rhTSH

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Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells.

Jane Koo, Caroline Lee, Won Gu Kim … (2008)

Recombinant glycoprotein therapeutics have proven to be invaluable pharmaceuticals for the treatment of various diseases. Chinese hamster ovary (CHO) cells are widely used in industry for the production of these proteins. Several strategies for engineering CHO cells for improved protein production have been tried with considerable results. The focus has mainly been to increase the specific productivity and to extend the culture longevity by preventing programmed cell death. These CHO cell engineering strategies, particularly those developed in Korea, are reviewed here.

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Glycosylation of recombinant proteins: problems and prospects.

Nigel Jenkins, Elisabeth M.A. Curling (1994)

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The Oligosaccharides of Glycoproteins: Bioprocess Factors Affecting Oligosaccharide Structure and their Effect on Glycoprotein Properties

James Rasmussen, Michael Gramer, Dana Andersen … (1991)

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Author and article information

Journal

Title: Applied Biochemistry and Biotechnology

Abbreviated Title: Appl Biochem Biotechnol

Publisher: Springer Nature

ISSN (Print): 0273-2289

ISSN (Electronic): 1559-0291

Publication date Created: June 2011

Publication date (Electronic): December 23 2010

Publication date (Print): June 2011

Volume: 164

Issue: 4

Pages: 401-409

Article

DOI: 10.1007/s12010-010-9143-5

SO-VID: 7d7f0c95-8d9f-4139-a333-b4c5aad151ff

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