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      Perturbation of TG‐43 parameters of the brachytherapy sources under insufficient scattering materials

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          Abstract

          In the recommendations of Task Group #43 from American Association of Physicists in Medicine (AAPM TG43), methods of brachytherapy source dosimetry are recommended, under full scattering conditions. However, in actual brachytherapy procedures, sources may not be surrounded by full scattering tissue in all directions. Clinical examples include high‐dose‐rate (HDR) brachytherapy of the breast or low‐dose‐rate (LDR) brachytherapy of ocular melanoma using eye plaque treatment with 125I and 103Pd. In this work, the impact of the missing tissue on the TG‐43–recommended dosimetric parameters of different brachytherapy sources was investigated. The impact of missing tissue on the TG‐43–recommended dosimetric parameters of 137Cs,192Ir, and 103Pd brachytherapy sources was investigated using the MCNP5 Monte Carlo code. These evaluations were performed by placing the sources at different locations inside a 30×30×30cm3 cubical water phantom and comparing the results with the values of the source located at the center of the phantom, which is in a full scattering condition. The differences between the thickness of the overlying tissues for different source positions and the thickness of the overlying tissue in full scattering condition is referred to as missing tissue. The results of these investigations indicate that values of the radial dose function and 2D anisotropy function vary as a function of the thickness of missing tissue, only in the direction of the missing tissue. These changes for radial dose function were up to 5%, 11%, and 8% for 137Cs,192Ir, and 103Pd, respectively. No significant changes are observed for the values of the dose rate constants. In this project, we have demonstrated that the TG‐43 dosimetric parameters may only change in the directions of the missing tissue. These results are more practical than the published data by different investigators in which a symmetric effect of the missing tissue on the dosimetric parameters of brachytherapy source are being considered, regardless of the implant geometry in real clinical cases.

          PACS number: 87.53.JW

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          Most cited references16

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          Dosimetry of interstitial brachytherapy sources: recommendations of the AAPM Radiation Therapy Committee Task Group No. 43. American Association of Physicists in Medicine.

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            Phantom size in brachytherapy source dosimetric studies.

            An important point to consider in a brachytherapy dosimetry study is the phantom size involved in calculations or experimental measurements. As pointed out by Williamson [Med. Phys. 18, 776-786 (1991)] this topic has a relevant influence on final dosimetric results. Presently, one-dimensional (1-D) algorithms and newly-developed 3-D correction algorithms are based on physics data that are obtained under full scatter conditions, i.e., assumed infinite phantom size. One can then assume that reference dose distributions in source dosimetry for photon brachytherapy should use an unbounded phantom size rather than phantom-like dimensions. Our aim in this paper is to study the effect of phantom size on brachytherapy for radionuclide 137Cs, 192Ir, 125I and 103Pd, mainly used for clinical purposes. Using the GEANT4 Monte Carlo code, we can ascertain effects on derived dosimetry parameters and functions to establish a distance dependent difference due to the absence of full scatter conditions. We have found that for 137Cs and 192Ir, a spherical phantom with a 40 cm radius is the equivalent of an unbounded phantom up to a distance of 20 cm from the source, as this size ensures full scatter conditions at this distance. For 125I and 103Pd, the required radius for the spherical phantom in order to ensure full scatter conditions at 10 cm from the source is R = 15 cm. A simple expression based on fits of the dose distributions for various phantom sizes has been developed for 137Cs and 192Ir in order to compare the dose rate distributions published for different phantom sizes. Using these relations it is possible to obtain radial dose functions for unbounded medium from bounded phantom ones.
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              Monte Carlo and TLD dosimetry of an 192Ir high dose-rate brachytherapy source.

              An analytical Monte Carlo simulation code has been used to perform dosimetry calculations around an 192Ir high dose-rate brachytherapy source utilized in the widely used microSelectron afterloaded system. Radial dose functions, dose rate constant and anisotropy functions, utilized in the AAPM Task Group 43 dose estimation formalism, have been calculated. In addition, measurements of anisotropy functions using LiF TLD-100 rods have been performed in a polystyrene phantom to support our Monte Carlo calculations. The energy dependence of LiF TLD response was investigated over the whole range of measurement distances and angles. TLD measurements and Monte Carlo calculations are in agreement to each other and agree with published data. The influence of phantom dimensions on calculations was also investigated. Radial dose functions were found to depend significantly on phantom dimensions at radial distances near phantom edges. Deviations of up to 25% are observed at these distances due to the lack of full scattering conditions, indicating that body dimensions should be taken into account in treatment planning when the absorbed dose is calculated near body edges. On the other hand, anisotropy functions do not demonstrate a strong dependence on phantom dimensions. However, these functions depend on radial distance at angles close to the longitudinal axis of the source, where deviations of up to 20% are observed.
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                Author and article information

                Contributors
                alimeig@gmail.com
                Journal
                J Appl Clin Med Phys
                J Appl Clin Med Phys
                10.1002/(ISSN)1526-9914
                ACM2
                Journal of Applied Clinical Medical Physics
                John Wiley and Sons Inc. (Hoboken )
                1526-9914
                06 May 2013
                May 2013
                : 14
                : 3 ( doiID: 10.1002/acm2.2013.14.issue-3 )
                : 164-176
                Affiliations
                [ 1 ] Department of Medical Engineering School of Mechanical Engineering Shiraz Fars Iran
                [ 2 ] Radiation Research Center Shiraz University Shiraz Fars Iran
                [ 3 ] Comprehensive Cancer Centers of Nevada Las Vegas Nevada USA
                Author notes
                [*] [* ] a Corresponding author: Ali S. Meigooni, Comprehensive Cancer Center of Nevada, 3730 S. Eastern Ave., Las Vegas, Nevada 89169, USA; phone: (+1) 702‐952‐3366 ext (5478); fax:(+1) 702‐952‐3727; email: alimeig@ 123456gmail.com

                Article
                ACM20164
                10.1120/jacmp.v14i3.4228
                5714407
                23652255
                7d2b9d61-9bb7-4aaa-8101-e91b0c3ee316
                © 2013 The Authors.

                This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 27 September 2012
                : 10 January 2013
                Page count
                Figures: 5, Tables: 5, References: 20, Pages: 13, Words: 4960
                Categories
                Radiation Oncology Physics
                Radiation Oncology Physics
                Custom metadata
                2.0
                acm20164
                May 2013
                Converter:WILEY_ML3GV2_TO_NLMPMC version:5.2.5 mode:remove_FC converted:16.11.2017

                tg‐43 brachytherapy,dosimetry,monte carlo,missing tissue,overlaying tissue

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