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Continuous Renal Replacement Therapy
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Abstract
Continuous renal replacement therapy (CRRT) is commonly used to provide renal support
for critically ill patients with acute kidney injury, particularly patients who are
hemodynamically unstable. A variety of techniques that differ in their mode of solute
clearance may be used, including continuous venovenous hemofiltration with predominantly
convective solute clearance, continuous venovenous hemodialysis with predominantly
diffusive solute clearance, and continuous venovenous hemodiafiltration, which combines
both dialysis and hemofiltration. The present article compares CRRT with other modalities
of renal support and reviews indications for initiation of renal replacement therapy,
as well as dosing and technical aspects in the management of CRRT.