E6 and E7 of human papillomavirus type 18 and UVB irradiation corporately regulate interleukin-6 and interleukin-8 expressions in basal cell carcinoma.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The lack of a human papillomavirus (HPV)-infected skin cancer cell line has hampered the investigation of the interaction of UV and HPV in skin carcinogenesis. We identified a human basal cell carcinoma (BCC-1/KMC) cell line integrated with E6 and E7 genes of high-risk HPV type 18 and demonstrated that repression of E6 and E7 results in proliferation inhibition. Sublethal ultraviolet-B (UVB) irradiation induced the expressions of interleukin-6 (IL-6) and interleukin-8 (IL-8), as well as viral E6 and E7 genes, in BCC-1/KMC cells. When E6 and E7 expressions were inhibited, IL-6/IL-8 expressions were repressed. Furthermore, IL-6/IL-8 remained inducible by UVB irradiation when E6 and E7 were inhibited. These results indicated that IL-6 and IL-8 can be upregulated by viral E6 and E7 proteins without UVB irradiation. Moreover, chronic exposure to UVB upregulates IL-6 and IL-8 when E6/E7 is induced by UVB.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Exp. Dermatol.

Title: Experimental dermatology

ISSN (Electronic): 1600-0625

ISSN (Print): 0906-6705

Publication date (Electronic): Oct 2013

Volume: 22

Issue: 10

Affiliations

[1 ] Department of Dermatology, Chung Shan Medical University Hospital, Taichung City, Taiwan; Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung City, Taiwan.

Article

DOI: 10.1111/exd.12223

PubMed ID: 24079741

SO-VID: 7bc09fdb-b475-4325-bbc7-19398b8b4fdb

History

Keywords: BCC,HPV,IL-6,IL-8,VUB

Data availability:

Keywords: BCC, HPV, IL-6, IL-8, VUB

Comments

Comment on this article

scite_

Cited by 3

See all cited by