JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy.

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Abstract

Inhaled lidocaine antagonized bronchospasm in animal models and patients, but adverse effects limited its efficacy. This study evaluated the antibronchospasm potential of the analog JM25-1, exploring in vitro mechanisms and translation to an animal model.

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Journal

Journal ID (iso-abbrev): Anesthesiology

Title: Anesthesiology

ISSN (Electronic): 1528-1175

ISSN (Print): 0003-3022

Publication date (Electronic): Jan 2016

Volume: 124

Issue: 1

Affiliations

[1 ] From the Laboratory of Inflammation (M.F.S., G.C.C., A.C.C., C.R.P., K.I.M.d.C., E.A.A.-V., J.C.S.C., R.S.B.C., P.M.R.S., M.A.M.) and Laboratory of Cellular Communication (R.X.F.), Oswaldo Cruz Institute, Rio de Janeiro, Brazil; and Institute of Biomedical Sciences (J.S.N.) and Laboratory of Clinical Bacteriology and Immunology (P.C.O.), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Article

Publisher Item ID: 00000542-201601000-00025

DOI: 10.1097/ALN.0000000000000919

PubMed ID: 26669988

SO-VID: 7b1b1a7f-b677-4b03-bd22-da37e10639c7

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